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Literature summary extracted from
- Microbial metabolism of 2-deoxyglucose; 2-deoxygluconic acid dehydrogenase (1965), Biochemistry, 4, 159-165.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.125 | FMN | stimulatory effect | Pseudomonas sp. |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.125 | NAD+ | inhibition at high concentrations | Pseudomonas sp. | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.125 | 1.54 | 5 | 2-deoxy-D-gluconate | - |
Pseudomonas sp. | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.125 | 2-deoxy-D-gluconate + NAD+ | Pseudomonas sp. | - |
3-dehydro-2-deoxy-D-gluconate + NADH | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.125 | Pseudomonas sp. | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.125 | partial | Pseudomonas sp. |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.125 | cell culture | inducible enzyme synthesis by growth in 2-deoxy-D-gluconate containing medium | Pseudomonas sp. | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.125 | 32 | - |
- |
Pseudomonas sp. |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.1.1.125 | -5°C, 10 days | Pseudomonas sp. |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.125 | 2-deoxy-D-gluconate + NAD+ | - |
Pseudomonas sp. | 3-dehydro-2-deoxy-D-gluconate + NADH | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.125 | 2-deoxygluconic acid dehydrogenase | - |
Pseudomonas sp. |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.125 | 7.9 | 8.9 | - |
Pseudomonas sp. |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.125 | NAD+ | can not be replaced by NADP+ | Pseudomonas sp. | |
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Release 2023.1 (January 2023)
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