Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hara, A.; Mouri, K.; Nakagawa, M.; Nakamura, M.; Nakayama, T.; Matsuura, K.; Saweda, H.
    Monkey liver indanol dehydrogenase. Purification, properties, and kinetic mechanism (1989), J. Biochem., 106, 126-132.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.112 1,10-phenanthroline competitive inhibition vs. indanol Macaca fuscata
1.1.1.112 2,2'-bipyridine competitive inhibition vs. indanol Macaca fuscata
1.1.1.112 4,4'-Bipyridine competitive inhibition vs. indanol Macaca fuscata
1.1.1.112 8-hydroxyquinoline competitive inhibition vs. indanol Macaca fuscata
1.1.1.112 Cibacron blue noncompetitive inhibition vs. indanol Macaca fuscata
1.1.1.112 Hexestrol competitive inhibition vs. indanol Macaca fuscata
1.1.1.112 Medroxyprogesterone acetate competitive inhibition vs. indanol Macaca fuscata
1.1.1.112 progesterone competitive inhibition vs. indanol Macaca fuscata

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.112 36000
-
 1 * 36000, SDS-PAGE Macaca fuscata
1.1.1.112 38000
-
 gel filtration Macaca fuscata

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.112 Macaca fuscata
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.112 ammonium sulfate, Sephadex G-100, Blue Sepharose, hydroxyapatite, chromatofocusing Macaca fuscata

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.112 indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+ A-stereospecific enzyme, ping-pong mechanism Macaca fuscata
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.112 brain
-
 Macaca fuscata
-
1.1.1.112 heart
-
 Macaca fuscata
-
1.1.1.112 kidney
-
 Macaca fuscata
-
1.1.1.112 liver
-
 Macaca fuscata
-
1.1.1.112 lung
-
 Macaca fuscata
-
1.1.1.112 spleen
-
 Macaca fuscata
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.112 11.1
-
 1-acenaphthenol as substrate Macaca fuscata

Storage Stability

EC Number Storage Stability Organism
1.1.1.112 4°C, 150 mM KCl, more than 1 mg/ml enzyme concentration, 4 months, little loss of activity Macaca fuscata

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.112 1,2,3,4-tetrahydro-1-naphthol + NAD(P)+
-
 Macaca fuscata 1,2,3,4-tetrahydro-1-naphthone + NAD(P)H
-
 ?
1.1.1.112 1-acenaphthenol + NAD(P)+
-
 Macaca fuscata 1-acenaphthenone + NAD(P)H
-
 ?
1.1.1.112 2,3-butanedione + NAD(P)H
-
 Macaca fuscata 2,3-butanediol + NAD(P)+
-
 ?
1.1.1.112 2,3-heptanedione + NAD(P)H
-
 Macaca fuscata 2,3-heptanediol + NAD(P)+
-
 ?
1.1.1.112 2-nitrobenzaldehyde + NAD(P)H
-
 Macaca fuscata 2-nitrobenzyl alcohol + NAD(P)+
-
 ?
1.1.1.112 3-nitrobenzaldehyde + NAD(P)H
-
 Macaca fuscata 3-nitrobenzyl alcohol + NAD(P)+
-
 ?
1.1.1.112 4-nitrobenzaldehyde + NAD(P)H
-
 Macaca fuscata 4-nitrobenzyl alcohol + NAD(P)+
-
 ?
1.1.1.112 benzene dihydrodiol + NAD(P)+
-
 Macaca fuscata o-benzoquinone + NAD(P)H
-
 ?
1.1.1.112 camphorquinone + NAD(P)H + H+
-
 Macaca fuscata camphane-2,3-diol + NAD(P)+
-
 ?
1.1.1.112 cyclohex-2-en-1-ol + NAD(P)+
-
 Macaca fuscata cyclohex-2-en-1-one + NAD(P)H
-
 ?
1.1.1.112 indan-(RS)-1-ol + NAD(P)+
-
 Macaca fuscata indan-1-one + NAD(P)H
-
 ?
1.1.1.112 indan-(S)-1-ol + NAD(P)+
-
 Macaca fuscata indan-1-one + NAD(P)H
-
 ?
1.1.1.112 indan-2-ol + NAD(P)+
-
 Macaca fuscata indan-2-one + NAD(P)H
-
 ?
1.1.1.112 trans-1,2-dihydroxy-1,2-dihydronaphthalene + NAD(P)+
-
 Macaca fuscata 1,2-naphthoquinone + NAD(P)H
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.112 monomer 1 * 36000, SDS-PAGE Macaca fuscata

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.1.1.112 15 50 linear increase Macaca fuscata

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.112 48
-
 60% activity lost after 10 min, pH 7.0 Macaca fuscata

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.112 5.4
-
-
 Macaca fuscata

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.1.1.112 5.2 10.5 10 min at 25°C Macaca fuscata

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.112 NAD+
-
 Macaca fuscata
1.1.1.112 NADP+ 5 times higher dehydrogenase rates compared to NAD+ Macaca fuscata