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Literature summary extracted from

  • Marcus, J.P.; Dekker, E.E.
    Identification of a second active site residue in Escherichia coli L-threonine dehydrogenase: methylation of histidin-90 with methyl p-nitrobenzenesulfonate (1995), Arch. Biochem. Biophys., 316, 413-420.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.103 methyl p-nitrobenzenesulfonate 2 mM, 40% inhibition within 80 min, 65% protection with 250 mM L-threonine, 64% with 250 mM L-threonine methyl ester, 58% with 250 mM L-threonine amide Escherichia coli K-12

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.103 0.0164
-
 NAD+
-
 Escherichia coli K-12
1.1.1.103 0.7
-
 L-threonine
-
 Escherichia coli K-12

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.103 L-threonine + NAD+ Escherichia coli K-12
-
 (2S)-2-amino-3-oxobutanoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.103 Escherichia coli K-12
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.103 L-threonine + NAD+
-
 Escherichia coli K-12 (2S)-2-amino-3-oxobutanoate + NADH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.103 NAD+
-
 Escherichia coli K-12