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Literature summary extracted from
- Stereospecificity of the NADPH-dependent reduction reaction of 3-oxodihydrosphingosine (2-amino-1-hydroxyoctadecane-3-one) (1968), Hoppe-Seyler's Z. Physiol. Chem., 349, 1637-1644.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.102 | 0.015 | - |
(S)-2-amino-1-hydroxyoctadecan-3-one | - |
Bos taurus |  |
| 1.1.1.102 | 0.03 | - |
(S)-2-amino-1-hydroxyeicosane-3-one | - |
Bos taurus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.102 | Bos taurus | - |
- |
- |
| 1.1.1.102 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.1.1.102 | Triton X-100, ammonium sulfate, calcium apatite, density gradient | Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.102 | brain | - |
Rattus norvegicus | - |
| 1.1.1.102 | cardiac muscle | - |
Rattus norvegicus | - |
| 1.1.1.102 | kidney | - |
Rattus norvegicus | - |
| 1.1.1.102 | liver | - |
Rattus norvegicus | - |
| 1.1.1.102 | liver | - |
Bos taurus | - |
| 1.1.1.102 | lung | - |
Rattus norvegicus | - |
| 1.1.1.102 | muscle | - |
Rattus norvegicus | - |
| 1.1.1.102 | spleen | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.102 | 25 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.102 | (S)-2-amino-1-hydroxyeicosane-3-one + NADPH | slower reduced than (S)-2-amino-1-hydroxyoctadecane-3-one | Bos taurus | (S)-2-amino-1-(R)-3-dihydroxyeicosane + NADP+ | - |
? | |
| 1.1.1.102 | (S)-2-amino-1-hydroxyoctadecan-3-one + NADPH | - |
Bos taurus | (S)-2-amino-1-(R)-3-dihydroxyoctadecane + NADP+ | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.102 | 6.5 | 7 | - |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.102 | NADPH | - |
Rattus norvegicus | |
| 1.1.1.102 | NADPH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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