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Literature summary extracted from

  • Ballas, L.M.; Bell, R.M.
    Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles (1981), Biochim. Biophys. Acta, 665, 586-595.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.101 Triton X-100 activation Rattus norvegicus

General Stability

EC Number General Stability Organism
1.1.1.101 chymotrypsin inactivates Rattus norvegicus
1.1.1.101 trypsin inactivates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.101 chymotrypsin inactivation Rattus norvegicus
1.1.1.101 Trypsin inactivation Rattus norvegicus
2.3.1.42 chymotrypsin intact vesicles Rattus norvegicus
2.3.1.42 Mercuridextran intact microsomes Rattus norvegicus
2.3.1.42 Trypsin intact vesicles Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.42 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Rattus norvegicus peroxisomal enzyme involved in ether lipid biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.101 Rattus norvegicus
-
 Charles River CD strain
-
1.1.1.101 Rattus norvegicus Charles River CD
-
 Charles River CD strain
-
2.3.1.42 Rattus norvegicus
-
 female Charles River CD-strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.101 liver
-
 Rattus norvegicus
-
2.3.1.42 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.101 0.00158
-
-
 Rattus norvegicus
2.3.1.42 0.00012
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.101 acyldihydroxyacetone phosphate + NADPH
-
 Rattus norvegicus 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 acyldihydroxyacetone phosphate + NADPH
-
 Rattus norvegicus Charles River CD 1-acyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+
-
 Rattus norvegicus 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 alkyldihydroxyacetone phosphate + NADPH + H+
-
 Rattus norvegicus Charles River CD 1-alkyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 hexadecyldihydroxyacetone phosphate + NADPH
-
 Rattus norvegicus 1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 hexadecyldihydroxyacetone phosphate + NADPH
-
 Rattus norvegicus Charles River CD 1-hexadecyl-sn-glycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 palmitoylglycerone phosphate + NADPH i.e. palmitoyldihydroxyacetone phosphate Rattus norvegicus 1-palmitoylglycerol 3-phosphate + NADP+
-
 ?
1.1.1.101 palmitoylglycerone phosphate + NADPH i.e. palmitoyldihydroxyacetone phosphate Rattus norvegicus Charles River CD 1-palmitoylglycerol 3-phosphate + NADP+
-
 ?
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus CoA + acyldihydroxyacetone phosphate i.e. acylglycerone phosphate ?
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus Charles River CD CoA + acyldihydroxyacetone phosphate i.e. acylglycerone phosphate ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate best substrate Rattus norvegicus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate peroxisomal enzyme involved in ether lipid biosynthesis Rattus norvegicus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.42 23
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.101 NADPH hydrogen from B-side of nicotinamide ring is transferred to reduce keto substrates Rattus norvegicus