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Literature summary extracted from
- Isolation and characterization of three alcohol dehydrogenase isozymes from Syrian golden hamster (1996), Alcohol. Clin. Exp. Res., 20, 213-220.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | 1,10-phenanthroline | - |
Mesocricetus auratus |  |
| 1.1.1.1 | 4-Methylpyrazole | isoenzyme AA-ADH, BB-ADH and TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | Biochanin A | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | daidzein | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | genistein | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | testosterone | inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.02 | - |
all-trans-retinol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.02 | - |
n-Hexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.02 | - |
12-hydroxydodecanoate | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.03 | - |
n-butanol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.03 | - |
all-trans-retinol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.04 | - |
Cyclohexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.04 | - |
n-Hexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.05 | - |
12-hydroxydodecanoate | isoenzyme BB-ADH and isoenzyme ADH-TT | Mesocricetus auratus | |
| 1.1.1.1 | 0.05 | - |
all-trans-retinol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.06 | - |
12-hydroxydodecanoate | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.07 | - |
n-butanol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.26 | - |
n-Hexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.5 | - |
ethanol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.76 | - |
ethanol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 0.76 | - |
Cyclohexanol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.3 | - |
12-hydroxydodecanoate | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.6 | - |
n-butanol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 28 | - |
ethanol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 320 | - |
Cyclohexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | Zinc | isoenzyme AA-ADH contains 4.3 zinc atoms per dimeric molecule, isoenzyme BB-ADH contains 3.7 zinc atoms per dimeric molecule, isoenzyme AA-ADH contains 4.1 zinc atoms per dimeric molecule | Mesocricetus auratus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 40000 | - |
2 * 40000, SDS-PAGE | Mesocricetus auratus |
| 1.1.1.1 | 80000 | - |
gel filtration | Mesocricetus auratus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | Mesocricetus auratus | - |
3 major isoenzymes: TT-ADH, AA-ADH and BB-ADH | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.1 | liver | isoenzyme AA-ADH and BB-ADH most abundant in | Mesocricetus auratus | - |
| 1.1.1.1 | testis | isoenzyme TT-ADH is only found in testis | Mesocricetus auratus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.1 | 2.1 | - |
isoenzyme AA-ADH | Mesocricetus auratus |
| 1.1.1.1 | 2.5 | - |
isoenzyme BB-ADH | Mesocricetus auratus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.1 | 12-hydroxydodecanoate + NAD+ | - |
Mesocricetus auratus | 12-oxododecanoic acid + NADH | - |
? | |
| 1.1.1.1 | 3beta-hydroxy-5beta-androstan-17-one + NAD+ | catalyzed by isoenzyme BB-ADH, no activity with isoenzyme AA-ADH and TT-ADH | Mesocricetus auratus | 5beta-androstan-3,17-dione + NADH | - |
? | |
| 1.1.1.1 | all-trans-retinol + NAD+ | - |
Mesocricetus auratus | all-trans-retinal + NADH | - |
? | |
| 1.1.1.1 | butan-2-ol + NAD+ | - |
Mesocricetus auratus | butan-2-one + NADH | - |
? | |
| 1.1.1.1 | butanol + NAD+ | - |
Mesocricetus auratus | butyraldehyde + NADH | - |
? | |
| 1.1.1.1 | cyclohexanol + NAD+ | - |
Mesocricetus auratus | cyclohexanone + NADH | - |
? | |
| 1.1.1.1 | ethanol + NAD+ | - |
Mesocricetus auratus | acetaldehyde + NADH | - |
? | |
| 1.1.1.1 | hexanol + NAD+ | - |
Mesocricetus auratus | n-hexanal + NADH | - |
? | |
| 1.1.1.1 | methylcrotonyl alcohol + NAD+ | - |
Mesocricetus auratus | methylcrotonaldehyde + NADH | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.1 | dimer | 2 * 40000, SDS-PAGE | Mesocricetus auratus |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.1.1.1 | 0.35 | - |
all-trans retinol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 1.03 | - |
12-hydroxydodecanoate | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 1.3 | - |
all-trans retinol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 1.75 | - |
Cyclohexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 1.9 | - |
all-trans retinol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.2 | - |
12-hydroxydodecanoate | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.35 | - |
n-Hexanol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.4 | - |
Cyclohexanol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.58 | - |
n-butanol | isoenzymee BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.63 | - |
methylcrotonyl alcohol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.77 | - |
12-hydroxydodecanoate | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.8 | - |
n-Hexanol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 2.83 | - |
ethanol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 3 | - |
methylcrotonyl alcohol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 3.33 | - |
n-butanol | isoenzyme AA-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 3.38 | - |
ethanol | isoenzyme BB-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 4.08 | - |
n-Hexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 7.18 | - |
n-butanol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 8.5 | - |
Cyclohexanol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 8.58 | - |
methylcrotonyl alcohol | isoenzyme TT-ADH | Mesocricetus auratus | |
| 1.1.1.1 | 9.58 | - |
ethanol | isoenzyme TT-ADH | Mesocricetus auratus | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.1 | NAD+ | - |
Mesocricetus auratus | |
| 1.1.1.1 | NADH | - |
Mesocricetus auratus | |
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