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Literature summary extracted from

  • Kedishvili, N.Y.; Bosron, W.F.; Stone, C.L.; Hurley, T.D.; Peggs, C.F.; Thomasson, H.R.; Popov, K.M.; Carr, L.G.; Edenberg, H.J.; Li, T.K.
    Expression and kinetic characterization of recombinant human stomach alcohol dehydrogenase. Active-site amino acid sequence explains substrate specificity copared with liver isozymes (1995), J. Biol. Chem., 270, 3625-3630.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.1 class IV enzyme, expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.1 4-methoxypyrazole
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 0.009
-
 all-trans-retinol
-
 Homo sapiens
1.1.1.1 0.048
-
 12-hydroxydodecanoate
-
 Homo sapiens
1.1.1.1 0.13
-
 Hexanol
-
 Homo sapiens
1.1.1.1 0.28
-
 Pentanol
-
 Homo sapiens
1.1.1.1 0.79
-
 butanol
-
 Homo sapiens
1.1.1.1 1.39
-
 Propanol
-
 Homo sapiens
1.1.1.1 28
-
 ethanol
-
 Homo sapiens
1.1.1.1 120
-
 (S)-2-butanol
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Homo sapiens
-
 class IV enzyme, sigma-ADH
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.1 stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 (S)-2-butanol + NAD+
-
 Homo sapiens butanone + NADH + H+
-
 r
1.1.1.1 12-hydroxydodecanoate + NAD+
-
 Homo sapiens 12-oxododecanoic acid + NADH
-
 ?
1.1.1.1 all-trans-retinol + NAD+
-
 Homo sapiens all-trans-retinal + NADH
-
 ?
1.1.1.1 butan-2-ol + NAD+
-
 Homo sapiens butan-2-one + NADH
-
 ?
1.1.1.1 butanol + NAD+
-
 Homo sapiens butyraldehyde + NADH
-
 ?
1.1.1.1 ethanol + NAD+
-
 Homo sapiens acetaldehyde + NADH
-
 ?
1.1.1.1 hexanol + NAD+
-
 Homo sapiens n-hexanal + NADH
-
 ?
1.1.1.1 pentanal + NAD+
-
 Homo sapiens pentanone + NADH
-
 ?
1.1.1.1 propanol + NAD+
-
 Homo sapiens propionaldehyde + NADH + H+
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.1 0.4
-
 all-trans-retinol
-
 Homo sapiens
1.1.1.1 2.17
-
 (S)-2-butanol
-
 Homo sapiens
1.1.1.1 2.95
-
 12-hydroxydodecanoate
-
 Homo sapiens
1.1.1.1 16
-
 Pentanol
-
 Homo sapiens
1.1.1.1 17.2
-
 Propanol
-
 Homo sapiens
1.1.1.1 19.5
-
 Hexanol
-
 Homo sapiens
1.1.1.1 30.7
-
 ethanol
-
 Homo sapiens
1.1.1.1 34.8
-
 butanol
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 NAD+
-
 Homo sapiens
1.1.1.1 NADH
-
 Homo sapiens