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Literature summary extracted from

  • Boon, W.C.; Roche, P.J.; Butkus, A.; McDougall, J.G.; Jeyaseelan, K.; Coghlan, J.P.
    Functional and expression analysis of ovine steroid 11beta-hydroxylase (cytochrome P 45011beta) (1997), Endocr. Res., 23, 325-347.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.15.4 cDNA transfected into COS-7 cells simultaneously with bovine adrenodoxin cDNA expression plasmid Ovis aries

Protein Variants

EC Number Protein Variants Comment Organism
1.14.15.4 additional information all enzymes with aldosterone synthesis activity have a glycine residue at position 288, in nonaldosterone synthesising P45011beta it is valine or serine Ovis aries

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.4 additional information conversion of labelled steroid to labelled aldosterone is inhibited by the addition of an excess of the same unlabelled steroid Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.4 mitochondrion from zona fasciculata Ovis aries 5739
-
1.14.15.4 mitochondrion from zona reticularis Ovis aries 5739
-
1.14.15.4 mitochondrion from zona glomerulosa Ovis aries 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.15.4 11-deoxycorticosterone + reduced adrenal ferredoxin + O2 Ovis aries 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 Ovis aries 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 corticosterone + reduced adrenal ferredoxin + O2 Ovis aries 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis 18-hydroxy-corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.4 Ovis aries
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.4 adrenal cortex
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.4 11-deoxycorticosterone + reduced adrenal ferredoxin + O2 11beta-hydroxylation Ovis aries corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 11-deoxycorticosterone + reduced adrenal ferredoxin + O2 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis Ovis aries corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis Ovis aries aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
 Ovis aries aldosterone + oxidized adrenal ferredoxin + H2O 18-hydroxylation ?
1.14.15.4 18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
 Ovis aries aldosterone + oxidized adrenal ferredoxin + H2O aldosterone production exclusively in the zona glomerulosa ?
1.14.15.4 corticosterone + reduced adrenal ferredoxin + O2 18-hydroxylation Ovis aries 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
1.14.15.4 corticosterone + reduced adrenal ferredoxin + O2 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis Ovis aries 18-hydroxy-corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?