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Literature summary extracted from

  • Grant, J.K.; Brownie, A.C.
    The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation (1955), Biochim. Biophys. Acta, 18, 433-434.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.15.4 2-oxoglutarate most potent activator in intact mitochondria Bos taurus
1.14.15.4 fumarate increase of activity Bos taurus
1.14.15.4 MnCl2 1 mM, reactivation of dialysed enzyme Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.15.4 EDTA 10 mM Bos taurus
1.14.15.4 KCN slight inhibitor Bos taurus
1.14.15.4 phosphate
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.15.4 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.4 Bos taurus
-
 ox
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.15.4 adrenal cortex
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.4 4-pregnen-21-ol-3,20-dione + reduced adrenal ferredoxin + O2 11-deoxycorticosterone, fumarate required in mitochondria treated with hypotonic solutions of electrolytes Bos taurus 4-pregnene-11,21-diol-3,20-dione + oxidized adrenal ferredoxin + H2O
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.15.4 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.15.4 7.4
-
 assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.4 NADPH no reaction with NADH or NADP+ Bos taurus