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Literature summary extracted from

  • Dawson, R.M.C.; Hemington, N.; Irvine, R.F.
    The inhibition and activation of Ca2+-dependent phosphatidylinositol phosphodiesterase by phospholipids and blood plasma (1980), Eur. J. Biochem., 112, 33-38.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 decanoylglycerophosphate only little activating effect Rattus norvegicus
3.1.4.11 decanoyllysophosphatidylcholine C10 lysophosphatidylcholine activates the reaction Rattus norvegicus
3.1.4.11 dihexanoylglycerophosphocholine
-
Rattus norvegicus
3.1.4.11 oleoylglycerophosphate activates the hydrolysis at a physiological pH Rattus norvegicus
3.1.4.11 palmitoylglycerophosphate activates the hydrolysis at a physiological pH Rattus norvegicus
3.1.4.11 phosphatidic acid activates the hydrolysis at a physiological pH Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 Blood lipoprotein enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins Rattus norvegicus
3.1.4.11 Blood plasma enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins Rattus norvegicus
3.1.4.11 Blood serum enzyme is strongly inhibited by blood plasma, serum and blood lipoproteins Rattus norvegicus
3.1.4.11 lysophosphatidylcholine C12, C14 and C16 lysophosphatidylcholines give progressive inhibition with increasing chain length Rattus norvegicus
3.1.4.11 phosphatidylcholine the enzyme is strongly inhibited when ovophosphatidylcholine and saturated phosphatidylcholines with acyl chain length of more than eight carbon atoms are mixed with its substrate Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.11 Ca2+ required Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 phosphatidylinositol + H2O
-
Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 Ca2 +-dependent phosphatidylinositol phosphodiesterase
-
Rattus norvegicus
3.1.4.11 phosphatidylinositol phosphodiesterase
-
Rattus norvegicus
3.1.4.11 phosphatidylinositol-phosphodiesterase
-
Rattus norvegicus