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Literature summary extracted from

  • Dawson, R.M.C.; Hemington, N.; Irvine, R.F.
    The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin (1985), Biochem. J., 230, 61-68.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 diacylglycerol 5-6fold stimulation of rat brain phosphatidylinositol phosphodiesterase. The addition of choline phospholipids containing two long hydrophobic chains or choline lysophospholipids containing one long hydrophobic chain produced a total inhibition of the activation which had been produced by diacylglycerol Rattus norvegicus
3.1.4.11 diacylglycerol the addition of choline phospholipids containing two long hydrophobic chains or choline lysophospholipids containing one long hydrophobic chain produced a total inhibition of the activation which had been produced by diacylglycerol Homo sapiens
3.1.4.11 phosphatidylethanolamine activates the hydrolysis. Human platelet phosphatidylinositol phosphodiesterase Homo sapiens
3.1.4.11 phosphatidylethanolamine activates the hydrolysis. Human platelet phosphatidylinositol phosphodiesterase Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.11 choline plasmalogen 18.5% of choline plasmalogen is needed for 50% inhibition Homo sapiens
3.1.4.11 choline plasmalogen 18.5% of choline plasmalogen is needed for 50% inhibition Rattus norvegicus
3.1.4.11 lysocholine plasmalogen 8.5% of choline plasmalogen is needed for 50% inhibition Homo sapiens
3.1.4.11 lysocholine plasmalogen 8.5% of choline plasmalogen is needed for 50% inhibition Rattus norvegicus
3.1.4.11 lysophosphatidylcholine 50% inhibition is produced by 7% molar Homo sapiens
3.1.4.11 lysophosphatidylcholine 50% inhibition is produced by 7% molar Rattus norvegicus
3.1.4.11 additional information enzyme is substantially inhibited by all phospholipids containing a phosphocholine head group. The sphingosine-containing phospholipids are the most inhibitory; phosphatidic acid does not inhibit Homo sapiens
3.1.4.11 additional information enzyme is substantially inhibited by all phospholipids containing a phosphocholine head group. The sphingosine-containing phospholipids are the most inhibitory; phosphatidic acid does not inhibit Rattus norvegicus
3.1.4.11 oleoyl sphingomyelin
-
 Homo sapiens
3.1.4.11 oleoyl sphingomyelin
-
 Rattus norvegicus
3.1.4.11 phosphatidylcholine low effect, 50% inhibition is produced by 18% molar egg phosphatidylcholine Homo sapiens
3.1.4.11 phosphatidylcholine little effect, 50% inhibition is produced by 18% molar egg phosphatidylcholine Rattus norvegicus
3.1.4.11 sphingomyelin 50% inhibition at 6.5% molar, and 97% at 20% molar Homo sapiens
3.1.4.11 sphingomyelin 50% inhibition at low concentration, and 97% at high concentration Rattus norvegicus
3.1.4.11 sphingosylphosphocholine
-
 Homo sapiens
3.1.4.11 sphingosylphosphocholine
-
 Rattus norvegicus
3.1.4.11 stearoyl sphingomyelin
-
 Homo sapiens
3.1.4.11 stearoyl sphingomyelin
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Homo sapiens
-
-
-
3.1.4.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.11 blood platelet
-
 Homo sapiens
-
3.1.4.11 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 phosphatidylinositol + H2O
-
 Rattus norvegicus 1D-myo-inositol 1-phosphate + diacylglycerol in vitro also inositol cyclic monophosphate formed ?
3.1.4.11 phosphatidylinositol + H2O
-
 Homo sapiens 1D-myo-inositol 1-phosphate + diacylglycerol in vitro myo-inositol 1,2-cyclic phosphate also formed ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 phosphatidylinositol phosphodiesterase
-
 Homo sapiens
3.1.4.11 phosphatidylinositol phosphodiesterase
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.11 6.8
-
 brain enzyme Rattus norvegicus
3.1.4.11 7.4
-
 platelet enzyme Homo sapiens