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Literature summary extracted from

  • Robinson, J.D.; Flashner, M.S.
    The (Na+ + K+)-activated ATPase. Enzymic and transport properties (1979), Biochim. Biophys. Acta, 549, 145-176.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 oligomycin inhibits (Na+,K+)-ATPase reaction and Na+-ATPase reaction, has little effect on the K+-phosphatase reaction and can stimulate the ADP/ATP exchange reaction Mammalia
7.2.2.13 oubain
-
 Mammalia

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.2.2.13 Mg2+ required Mammalia

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.2.2.13 250000 300000 radiation inactivation , gel filtration Mammalia
7.2.2.13 380000
-
 equilibrium centrifugation Mammalia

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Electrophorus electricus
-
-
-
7.2.2.13 Mammalia
-
-
-
7.2.2.13 shark
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
7.2.2.13 ATP + H2O + Na+[side 1] + K+[side 2] = ADP + phosphate + Na+[side 2] + K+[side 1] reaction sequence and transport mechanism Mammalia
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.13 electric organ
-
 Electrophorus electricus
-
7.2.2.13 kidney medulla Mammalia
-
7.2.2.13 rectal gland
-
 shark
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 Mammalia ADP + phosphate + Na+/out + K+/in
-
 ?
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 shark ADP + phosphate + Na+/out + K+/in
-
 ?
7.2.2.13 ATP + H2O + Na+/in + K+/out
-
 Electrophorus electricus ADP + phosphate + Na+/out + K+/in
-
 ?
7.2.2.13 additional information the enzyme also catalyzes: 1. uncoupled Na+ efflux in presence of Na+/in, Mg2+ and ATP, 2. Na+-dependent ADP/ATP exchange, 3. K+-dependent enzyme phosphorylation by phosphate Mammalia ?
-
 ?