EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
7.2.2.12 | E470A | metal ion-stimulated activity is reduced, about 30-40%. Mutant is phosphorylated more strongly in comparison to the wild type enzyme | Escherichia coli |
7.2.2.12 | H475Q | metal ion-stimulated activity is reduced, about 30-40%. Mutant is phosphorylated more weakly in comparison to the wild type enzyme. Mutation affects the reaction with ATP and phosphate and stabilizes the enzyme in a dephosphorylated state | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.2.2.12 | Cu2+ | prevents Zn2+ activation when present in 2fold excess over Zn2+ | Escherichia coli | |
7.2.2.12 | vanadate | - |
Escherichia coli |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
7.2.2.12 | membrane | - |
Escherichia coli | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
7.2.2.12 | Ag+ | activates ATPase activity | Escherichia coli | |
7.2.2.12 | Cu2+ | enhances phosphorylation, it cannot activate the ATPase | Escherichia coli |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
7.2.2.12 | 92000 | - |
1 * 92000, also detection of a dimeric form of 190000 Da, SDS-PAGE | Escherichia coli |
7.2.2.12 | 92000 | - |
2 * 92000, also detection of a monomeric form of 92000 Da, SDS-PAGE | Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.2.2.12 | Escherichia coli | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.2.2.12 | ATP + H2O + Ag+/in | - |
Escherichia coli | ADP + phosphate + Ag+/out | - |
? | |
7.2.2.12 | ATP + H2O + Cd2+/in | - |
Escherichia coli | ADP + phosphate + Cd2+/out | - |
? | |
7.2.2.12 | ATP + H2O + Pb2+/in | - |
Escherichia coli | ADP + phosphate + Pb2+/out | - |
? | |
7.2.2.12 | ATP + H2O + Zn2+/in | - |
Escherichia coli | ADP + phosphate + Zn2+/out | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
7.2.2.12 | dimer | 2 * 92000, also detection of a monomeric form of 92000 Da, SDS-PAGE | Escherichia coli |
7.2.2.12 | monomer | 1 * 92000, also detection of a dimeric form of 190000 Da, SDS-PAGE | Escherichia coli |
7.2.2.12 | More | - |
Escherichia coli |