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Literature summary extracted from
- Characterization of transport through the periplasmic histidine permease using proteoliposomes reconstituted by dialysis (1997), J. Biol. Chem., 272, 859-866.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.4.2.1 | histidine-binding protein | required | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 7.4.2.1 | histidine-binding protein | required | Escherichia coli | |
| 7.4.2.1 | histidine-binding protein | Km: 0.008 mM | Salmonella enterica subsp. enterica serovar Typhimurium |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.4.2.1 | ADP | - |
Salmonella enterica subsp. enterica serovar Typhimurium |  |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.4.2.1 | 8 | - |
ATP | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.4.2.1 | membrane | bound to | Salmonella enterica subsp. enterica serovar Typhimurium | 16020 | - |
| 7.4.2.1 | membrane | bound to | Escherichia coli | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.4.2.1 | Mg2+ | required for both transport and ATPase activity | Salmonella enterica subsp. enterica serovar Typhimurium | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.4.2.1 | Escherichia coli | - |
- |
- |
| 7.4.2.1 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 7.4.2.1 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.4.2.1 | ATP + H2O + His/out | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ADP + phosphate + His/in | - |
? | |
| 7.4.2.1 | ATP + H2O + His/out | - |
Escherichia coli | ADP + phosphate + His/in | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.4.2.1 | More | the membrane-bound enzyme complex contains four subunits and a soluble receptor | Salmonella enterica subsp. enterica serovar Typhimurium |
| 7.4.2.1 | More | the membrane-bound enzyme complex contains four subunits and a soluble receptor | Escherichia coli |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.4.2.1 | 46 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Temperature Range [°C]
| EC Number | Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.4.2.1 | 30 | 55 | 30°C: about 40% of maximal activity, 55°C: about 80% of maximal activity | Salmonella enterica subsp. enterica serovar Typhimurium |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.4.2.1 | 7.5 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 7.4.2.1 | 6 | 9.5 | about 30% of maximal activity at pH 6.0 and at pH 9.5 | Salmonella enterica subsp. enterica serovar Typhimurium |
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