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Literature summary extracted from

  • Staab, J.F.; Fosmire, S.; Zhang, M.; Varley, A.W.; Munford, R.S.
    Distinctive structural features are shared by human, lapine, and murine acloxyacyl hydrolases (1999), J. Endotoxin Res., 5, 205-208.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.77 in BHK 570 cells Mus musculus
3.1.1.77 in BHK 570 cells Homo sapiens
3.1.1.77 in BHK 570 cells Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.77 0.0005
-
 lipopolysaccharide
-
 Mus musculus
3.1.1.77 0.0005
-
 lipopolysaccharide
-
 Oryctolagus cuniculus
3.1.1.77 0.0006
-
 lipopolysaccharide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin Mus musculus detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin Homo sapiens detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin Oryctolagus cuniculus detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.77 Homo sapiens
-
-
-
3.1.1.77 Mus musculus
-
-
-
3.1.1.77 Oryctolagus cuniculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.77 glycoprotein
-
 Homo sapiens
3.1.1.77 glycoprotein small subunit not glycosylated Mus musculus
3.1.1.77 glycoprotein only three glycosylation sites in large subunit Mus musculus
3.1.1.77 glycoprotein only three glycosylation sites in large subunit Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Oryctolagus cuniculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O
-
 Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O
-
 Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 3-(acyloxy)acyl group of bacterial toxin + H2O
-
 Oryctolagus cuniculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
 ?
3.1.1.77 lipopolysaccharide + H2O
-
 Mus musculus ?
-
 ?
3.1.1.77 lipopolysaccharide + H2O
-
 Homo sapiens ?
-
 ?
3.1.1.77 lipopolysaccharide + H2O
-
 Oryctolagus cuniculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.77 dimer disufide linked hetrodimer Mus musculus
3.1.1.77 dimer disufide linked hetrodimer Homo sapiens
3.1.1.77 dimer disufide linked hetrodimer Oryctolagus cuniculus