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Literature summary extracted from
- Investigation of the Bacillus cereus phosphonoacetaldehyde hydrolase. Evidence for a Schiff base mechanism and sequence analysis of an active-site peptide containing the catalytic lysine residue (1988), Biochemistry, 27, 2229-2234.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.11.1.1 | acetonylphosphonate | - |
Bacillus cereus |  |
| 3.11.1.1 | NaBH4 | in presence of phosphonoacetaldehyde or acetaldehyde; no effect in absence of substrate or product | Bacillus cereus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.11.1.1 | 0.04 | - |
phosphonoacetaldehyde | - |
Bacillus cereus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.11.1.1 | Mg2+ | required | Bacillus cereus | |
| 3.11.1.1 | Mg2+ | stabilizes the active homodimer form of the enzyme | Bacillus cereus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.11.1.1 | phosphonoacetylaldehyde + H2O | Bacillus cereus | second step in the pathway by which Bacillus cereus metabolizes 2-aminoethylphosphonic acid | acetaldehyde + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.11.1.1 | Bacillus cereus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.11.1.1 | - |
Bacillus cereus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.11.1.1 | phosphonoacetaldehyde + H2O = acetaldehyde + phosphate | Schiff base mechanism | Bacillus cereus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.11.1.1 | phosphonoacetylaldehyde + H2O | - |
Bacillus cereus | acetaldehyde + phosphate | - |
? | |
| 3.11.1.1 | phosphonoacetylaldehyde + H2O | second step in the pathway by which Bacillus cereus metabolizes 2-aminoethylphosphonic acid | Bacillus cereus | acetaldehyde + phosphate | - |
? | |
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