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Literature summary extracted from
- UDP-galactose-4-epimerase (1975), ubunit enzymes: biochemistry and function (Ebner, K. B., ed.), 2, 85-135.
No PubMed abstract available
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.3.2 | 5'-UMP | - |
Bos taurus |  |
| 5.1.3.2 | 5'-UMP | the native enzyme is completely insensitive to inhibition, the desensitized enzyme is strongly inhibited. Desensitization by heat converts the enzyme to its ultimate catalytic form | Escherichia coli | |
| 5.1.3.2 | 5'-UMP | - |
Saccharomyces fragilis | |
| 5.1.3.2 | 5'-UMP | - |
Torulopsis candida | |
| 5.1.3.2 | 5-(adenosine-5'-diphosphoryl)-D-ribose | reductive inhibition | Escherichia coli | |
| 5.1.3.2 | 5-(thymidine-5'-diphosphoryl)-D-glucose | reductive inhibition | Escherichia coli | |
| 5.1.3.2 | 5-(Thymidine-5'-diphosphoryl)-D-ribose | reductive inhibition | Escherichia coli | |
| 5.1.3.2 | D-galactose | - |
Torulopsis candida | |
| 5.1.3.2 | glucose plus UMP | - |
Escherichia coli | |
| 5.1.3.2 | glucose plus UMP | - |
Torulopsis candida | |
| 5.1.3.2 | NaBH4 | reductive inhibition | Escherichia coli | |
| 5.1.3.2 | NADH | - |
Bos taurus | |
| 5.1.3.2 | NADH | - |
Escherichia coli | |
| 5.1.3.2 | Thymidine diphospho-6-deoxy-D-xylo-4-hexosulose | reductive inhibition | Escherichia coli |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.3.2 | 0.16 | - |
UDPgalactose | - |
Escherichia coli | |
| 5.1.3.2 | 1.2 | - |
UDPgalactose | - |
Torulopsis candida | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.1.3.2 | 40000 | - |
2 * 40000, SDS-PAGE | Escherichia coli |
| 5.1.3.2 | 60000 | - |
2 * 60000, enzyme exists in an active dimeric and an active tetrameric form | Kluyveromyces marxianus |
| 5.1.3.2 | 60000 | - |
4 * 60000, enzyme exists in an active dimeric and an active tetrameric form | Kluyveromyces marxianus |
| 5.1.3.2 | 80000 | - |
sedimentation equilibrium studies | Escherichia coli |
| 5.1.3.2 | 120000 | - |
sedimentation equilibrium measurement, addition of NAD+, active dimeric enzyme form | Kluyveromyces marxianus |
| 5.1.3.2 | 240000 | - |
sedimentation equilibrium measurement, addition of NAD+, 0.01 M Tris buffer with cations, active tetrameric form | Kluyveromyces marxianus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.3.2 | Bos taurus | - |
- |
- |
| 5.1.3.2 | Escherichia coli | - |
- |
- |
| 5.1.3.2 | Kluyveromyces marxianus | - |
- |
- |
| 5.1.3.2 | Saccharomyces fragilis | - |
- |
- |
| 5.1.3.2 | Torulopsis candida | - |
- |
- |
| 5.1.3.2 | Vigna radiata var. radiata | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.1.3.2 | liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.3.2 | ADP-D-glucose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | CDP-D-glucose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | Deoxy-UDP-D-glucose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | TDP-6-deoxy-D-galactose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | TDP-D-glucose | - |
Escherichia coli | TDP-D-galactose | - |
? | |
| 5.1.3.2 | UDP-6-deoxy-D-glucose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | UDP-D-fucose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | UDP-D-galactose-hexodialose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | UDP-D-xylose | - |
Escherichia coli | ? | - |
? | |
| 5.1.3.2 | UDP-galactose | - |
Vigna radiata var. radiata | UDP-glucose | - |
? | |
| 5.1.3.2 | UDP-galactose | - |
Escherichia coli | UDP-glucose | - |
? | |
| 5.1.3.2 | UDP-galactose | - |
Bos taurus | UDP-glucose | - |
? | |
| 5.1.3.2 | UDP-galactose | - |
Saccharomyces fragilis | UDP-glucose | - |
? | |
| 5.1.3.2 | UDP-galactose | - |
Kluyveromyces marxianus | UDP-glucose | - |
? | |
| 5.1.3.2 | UDP-galactose | - |
Torulopsis candida | UDP-glucose | - |
? | |
| 5.1.3.2 | UDP-L-arabinose | - |
Escherichia coli | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.1.3.2 | dimer | 2 * 40000, SDS-PAGE | Escherichia coli |
| 5.1.3.2 | dimer | 2 * 60000, enzyme exists in an active dimeric and an active tetrameric form | Kluyveromyces marxianus |
| 5.1.3.2 | tetramer | - |
Escherichia coli |
| 5.1.3.2 | tetramer | 4 * 60000, enzyme exists in an active dimeric and an active tetrameric form | Kluyveromyces marxianus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.3.2 | NAD+ | - |
Escherichia coli | |
| 5.1.3.2 | NAD+ | - |
Bos taurus | |
| 5.1.3.2 | NAD+ | depends on addition of NAD+ for catalytic acitivity, Km: 0.14 mM. Cannot be replaced by NADP+ | Torulopsis candida | |
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