EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.3.113 | 0.0021 | - |
geranyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.113 | 0.0021 | - |
neryl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.113 | 0.003 | - |
geranyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.113 | 0.0035 | - |
(3S)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.113 | 0.0035 | - |
(3R)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.113 | 0.004 | - |
(3R)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.113 | 0.0049 | - |
(3S)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.113 | 0.006 | - |
neryl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.119 | 0.0021 | - |
neryl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.119 | 0.003 | - |
geranyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.119 | 0.0035 | - |
(3S)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.119 | 0.0035 | - |
(3R)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.120 | 0.003 | - |
geranyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.121 | 0.0021 | - |
geranyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.121 | 0.004 | - |
(3R)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.121 | 0.0049 | - |
(3S)-linalyl diphosphate | pH 6.5, 30°C | Salvia officinalis | |
4.2.3.121 | 0.006 | - |
neryl diphosphate | pH 6.5, 30°C | Salvia officinalis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.3.113 | Salvia officinalis | - |
- |
- |
4.2.3.119 | Salvia officinalis | - |
- |
- |
4.2.3.120 | Salvia officinalis | - |
- |
- |
4.2.3.121 | Salvia officinalis | - |
- |
- |
4.2.3.122 | Salvia officinalis | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.3.113 | (3R)-linalyl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 17% (-)-alpha-pinene, 9% beta-pinene, 3% camphene, 28% limonene, 9% terpinolene, 23% myrcene, 3% cis-ocimene, 13% trans-ocimene | ? | |
4.2.3.113 | (3R)-linalyl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 62% (+)-alpha-pinene, 6% camphene, 11% limonene, 7% terpinolene, 10% myrcene, 1% cis-ocimene, 4% trans-ocimene | ? | |
4.2.3.113 | (3S)-linalyl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 15% (-)-alpha-pinene, 18% beta-pinene, 12% camphene, 11% limonene, 6% terpinolene, 23% myrcene, 3% cis-ocimene, 8% trans-ocimene | ? | |
4.2.3.113 | (3S)-linalyl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 9% (+)-alpha-pinene, 9% camphene, 34% limonene, 28%% terpinolene, 11% myrcene, 2% cis-ocimene, 6% trans-ocimene | ? | |
4.2.3.113 | geranyl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 28% (-)-alpha-pinene, 35% beta-pinene, 24% camphene, 5% limonene, 2% terpinolene, 6% myrcene | ? | |
4.2.3.113 | geranyl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 49% (+)-alpha-pinene, 30% camphene, 10% limonene, 5% terpinolene, 6% myrcene | ? | |
4.2.3.113 | additional information | reaction follows a cisoid, anti-endo-pattern. In the case of geranyl diphosphate, a preassociation mechanism is suggested in which optimum folding of the terpenyl chain precedes the initial ionization step. The alternate substratse are ionized by the cyclases prior to their achieving the optimum orientation for bicyclization | Salvia officinalis | ? | - |
? | |
4.2.3.113 | neryl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 14% (+)-alpha-pinene, 9% camphene, 62% limonene, 8% terpinolene, 6% myrcene | ? | |
4.2.3.113 | neryl diphosphate | - |
Salvia officinalis | terpinolene + diphosphate | products are 18% (-)-alpha-pinene, 18% beta-pinene, 12% camphene, 42% limonene, 9% terpinolene, 9% myrcene | ? | |
4.2.3.119 | (3R)-linalyl diphosphate | - |
Salvia officinalis | (-)-alpha-pinene + diphosphate | products are 17% (-)-alpha-pinene, 9% beta-pinene, 3% camphene, 28% limonene, 9% terpinolene, 23% myrcene, 3% cis-ocimene, 13% trans-ocimene | ? | |
4.2.3.119 | (3S)-linalyl diphosphate | - |
Salvia officinalis | (-)-alpha-pinene + diphosphate | products are 15% (-)-alpha-pinene, 18% beta-pinene, 12% camphene, 11% limonene, 6% terpinolene, 23% myrcene, 3% cis-ocimene, 8% trans-ocimene | ? | |
4.2.3.119 | geranyl diphosphate | - |
Salvia officinalis | (-)-alpha-pinene + diphosphate | products are 28% (-)-alpha-pinene, 35% beta-pinene, 24% camphene, 5% limonene, 2% terpinolene, 6% myrcene | ? | |
4.2.3.119 | additional information | reaction follows a cisoid, anti-endo-pattern. In the case of geranyl diphosphate, a preassociation mechanism is suggested in which optimum folding of the terpenyl chain precedes the initial ionization step. The alternate substrates are ionized by the cyclases prior to their achieving the optimum orientation for bicyclization | Salvia officinalis | ? | - |
? | |
4.2.3.119 | neryl diphosphate | - |
Salvia officinalis | (-)-alpha-pinene + diphosphate | products are 18% (-)-alpha-pinene, 18% beta-pinene, 12% camphene, 42% limonene, 9% terpinolene, 9% myrcene | ? | |
4.2.3.120 | geranyl diphosphate | - |
Salvia officinalis | (-)-beta-pinene | products are 28% (-)-alpha-pinene, 35% (-)-beta-pinene, 24% (+)-camphene, 5% (+)-limonene, plus some terpinolene and myrcene | ? | |
4.2.3.120 | additional information | bicyclic products pinene and camphene are derived via the cyclization of the bound, tertiary intermediate (3R)-linalyl diphosphate. Limonene is formed via conformational foldings in addition to the cisoid,anti-endo-pattern. In the case of geranyl diphosphate, a preassociation mechanism is suggested in which optimum folding of the terpenyl chain precedes the initial ionization step | Salvia officinalis | ? | - |
? | |
4.2.3.121 | (3R)-linalyl diphosphate | - |
Salvia officinalis | (+)-alpha-pinene + diphosphate | products are 62% (+)-alpha-pinene, 6% camphene, 11% limonene, 7% terpinolene, 10% myrcene, 1% cis-ocimene, 4% trans-ocimene | ? | |
4.2.3.121 | (3S)-linalyl diphosphate | - |
Salvia officinalis | (+)-alpha-pinene + diphosphate | products are 9% (+)-alpha-pinene, 9% camphene, 34% limonene, 28%% terpinolene, 11% myrcene, 2% cis-ocimene, 6% trans-ocimene | ? | |
4.2.3.121 | geranyl diphosphate | - |
Salvia officinalis | (+)-alpha-pinene + diphosphate | products are 49% (+)-alpha-pinene, 30% camphene, 10% limonene, 5% terpinolene, 6% myrcene | ? | |
4.2.3.121 | additional information | reaction follows a cisoid,anti-endo-pattern. In the case of geranyl diphosphate, a preassociation mechanism is suggested in which optimum folding of the terpenyl chain precedes the initial ionization step. The alternate substrates are ionized by the cyclases prior to their achieving the optimum orientation for bicyclization | Salvia officinalis | ? | - |
? | |
4.2.3.121 | neryl diphosphate | - |
Salvia officinalis | (+)-alpha-pinene + diphosphate | products are 14% (+)-alpha-pinene, 9% camphene, 62% limonene, 8% terpinolene, 6% myrcene | ? | |
4.2.3.122 | geranyl diphosphate | - |
Salvia officinalis | (+)-alpha-pinene + diphosphate | products are (+)-alpha-pinene, (+)-camphene, and lesser amounts of (+)-limonene, myrcene, and terpinolene. The bicyclic products of pinene and camphene are derived via the cyclization of the cisoid, anti-endo-conformers of the bound, tertiary allylic intermediate (3R)-linalyl diphosphate. A preassociation mechanism of geranyl diphosphate is suggested in which optimum folding of the terpenyl chain precedes the initial ionization step | ? | |
4.2.3.122 | linalyl diphosphate | - |
Salvia officinalis | myrcene + diphosphate | products are disproportionately high levels of acyclic olefins myrcene and ocimene and monocyclic olefins limonene and terpinolene. Limonene is formed via conformational foldings in addition to the cisoid, anti-endo-pattern | ? | |
4.2.3.122 | neryl diphosphate | - |
Salvia officinalis | myrcene + diphosphate | products are disproportionately high levels of acyclic olefins myrcene and ocimene and monocyclic olefins limonene and terpinolene. Limonene is formed via conformational foldings in addition to the cisoid, anti-endo-pattern | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.3.113 | (+)-pinene cyclase | - |
Salvia officinalis |
4.2.3.113 | (-)-pinene cyclase | - |
Salvia officinalis |
4.2.3.119 | (-)-pinene cyclase | - |
Salvia officinalis |
4.2.3.121 | (+)-pinene cyclase | - |
Salvia officinalis |