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Literature summary extracted from

  • Loe, D.W.; Stewart, R.K.; Massey, T.E.; Deeley, R.G.; Cole, S.P.C.
    ATP-dependent transport of aflatoxin B1 and its glutathione conjugate by the product of the multidrug resistance protein (MRP) gene (1997), Mol. Pharmacol., 51, 1034-1041.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 16alpha-17beta-estradiol 17-(beta-D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 17-beta-estradiol 17-beta-(D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 17beta-estradiol 16-(beta-D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 17beta-estradiol 3-sulfato-17-(beta-D-glucuronide) transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 GSSG transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 leukotriene D4 transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 monoclonal antibiodies
-
 Homo sapiens
7.6.2.2 S-butyl glutathione transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 S-decyl-glutathione
-
 Homo sapiens
7.6.2.2 S-hexyl glutathione transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens
7.6.2.2 S-octyl glutathione transport of aflatoxin B1-epoxide-GSH conjugate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.6.2.2 0.000189
-
 aflatoxin B1-epoxide-GSH conjugate/in
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Homo sapiens potential protective role for the enzyme in chemical carcinogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 H69 cell
-
 Homo sapiens
-
7.6.2.2 HEK-293 cell
-
 Homo sapiens
-
7.6.2.2 HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 aflatoxin B1-epoxide-GSH conjugate/in + ATP + H2O
-
 Homo sapiens aflatoxin B1-epoxide-GSH conjugate/out + ADP + phosphate
-
 ?
7.6.2.2 aflatoxin B1/in + ATP + H2O
-
 Homo sapiens aflatoxin B1/out + ADP + phosphate
-
 ?
7.6.2.2 additional information potential protective role for the enzyme in chemical carcinogenesis Homo sapiens ?
-
 ?