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Literature summary extracted from

  • Mao, Q.; Deeley, R.G.; Vole, S.P.C.
    Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles (2000), J. Biol. Chem., 275, 34166-34172.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.2 GSH stimulates transport of vincristine Homo sapiens
7.6.2.2 verapamil stimulates transport of vincristine Homo sapiens
7.6.2.2 vincristine stimulates transport of GSH Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 17-beta-estradiol 17-beta-(D-glucuronide)
-
 Homo sapiens
7.6.2.2 GSSG
-
 Homo sapiens
7.6.2.2 S-decyl-glutathione competitive Homo sapiens
7.6.2.2 vincristine alone is a very poor inhibitor of transport of leukotriene C4, together with GSH acts as relatively potent competitive inhibitor Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.6.2.2 0.000036
-
 leukotriene C4/in
-
 Homo sapiens
7.6.2.2 0.2
-
 ATP
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane transmembrane protein Homo sapiens 16020
-
7.6.2.2 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Homo sapiens MRP1 is an efflux pump, which can transport conjugated organic anions and cotansport vincristine together with GSH ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
7.6.2.2
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 H69AR cell
-
 Homo sapiens
-
7.6.2.2 HEK-293 cell
-
 Homo sapiens
-
7.6.2.2 HL-60 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 leukotriene C4/in + ATP + H2O
-
 Homo sapiens leukotriene C4/out + ADP + phosphate
-
 ?
7.6.2.2 additional information MRP1 is an efflux pump, which can transport conjugated organic anions and cotansport vincristine together with GSH Homo sapiens ?
-
 ?
7.6.2.2 vincristine/in + ATP + H2O requires cotransport of GSH Homo sapiens vincristine/out + ADP + phosphate
-
 ?