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Literature summary extracted from

  • Keppler, D.; König, J.; Buchler, M.
    The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes (1997), Adv. Enzyme Regul., 37, 321-333.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.6.2.2 0.00025
-
leukotriene C4/in
-
Rattus norvegicus
7.6.2.2 0.111
-
GSSG/in
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.2 membrane
-
Homo sapiens 16020
-
7.6.2.2 membrane
-
Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Rattus norvegicus
-
?
-
?
7.6.2.2 additional information Homo sapiens the deficient expression of cMRP appears as the basis of the transport defect in human Dubin-Johnson syndrome ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-
7.6.2.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 hepatocyte
-
Homo sapiens
-
7.6.2.2 hepatocyte
-
Rattus norvegicus
-
7.6.2.2 liver
-
Homo sapiens
-
7.6.2.2 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 3alpha-sulfatolithocholyltaurine/in + ATP + H2O
-
Rattus norvegicus 3alpha-sulfatolithocholyltaurine/out + ADP + phosphate
-
?
7.6.2.2 ATP + H2O + GSSG/in
-
Rattus norvegicus ADP + phosphate + GSSG/out
-
?
7.6.2.2 estradiol 17-beta-D-glucuronide/in + ATP + H2O
-
Homo sapiens estradiol 17-beta-D-glucuronide/out + ADP + phosphate
-
?
7.6.2.2 estradiol 17-beta-D-glucuronide/in + ATP + H2O
-
Rattus norvegicus estradiol 17-beta-D-glucuronide/out + ADP + phosphate
-
?
7.6.2.2 GSH/in + ATP + H2O
-
Rattus norvegicus GSH/out + ADP + phosphate
-
?
7.6.2.2 leukotriene C4/in + ATP + H2O
-
Homo sapiens leukotriene C4/out + ADP + phosphate
-
?
7.6.2.2 leukotriene C4/in + ATP + H2O
-
Rattus norvegicus leukotriene C4/out + ADP + phosphate
-
?
7.6.2.2 leukotriene D4/in + ATP + H2O
-
Homo sapiens leukotriene D4/out + ADP + phosphate
-
?
7.6.2.2 leukotriene D4/in + ATP + H2O
-
Rattus norvegicus leukotriene D4/out + ADP + phosphate
-
?
7.6.2.2 additional information
-
Rattus norvegicus ?
-
?
7.6.2.2 additional information the deficient expression of cMRP appears as the basis of the transport defect in human Dubin-Johnson syndrome Homo sapiens ?
-
?
7.6.2.2 S-(2,4-dinitrophenyl)glutathione/in + ATP + H2O
-
Homo sapiens S-(2,4-dinitrophenyl)glutathione/out + ADP + phosphate
-
?
7.6.2.2 S-(2,4-dinitrophenyl)glutathione/in + ATP + H2O
-
Rattus norvegicus S-(2,4-dinitrophenyl)glutathione/out + ADP + phosphate
-
?