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Literature summary extracted from
- The ABC family of multidrug transporters in microorganisms (1998), Biochim. Biophys. Acta, 1365, 31-36.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | additional information | Homo sapiens | overexpression of the multidrug resistance P-glycoprotein and the multidrug resistance-associated protein MRP1 is a principal cause of resistance of cancer to chemotherapy | ? | - |
? |  |
| 7.6.2.2 | additional information | Entamoeba histolytica | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | ? | - |
? | |
| 7.6.2.2 | additional information | Leishmania donovani | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | ? | - |
? | |
| 7.6.2.2 | additional information | Candida albicans | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | ? | - |
? | |
| 7.6.2.2 | additional information | Plasmodium falciparum | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | Bacillus subtilis | - |
- |
- |
| 7.6.2.2 | Caenorhabditis elegans | - |
- |
- |
| 7.6.2.2 | Candida albicans | - |
- |
- |
| 7.6.2.2 | Cricetulus griseus | - |
chinese hamster | - |
| 7.6.2.2 | Entamoeba histolytica | - |
- |
- |
| 7.6.2.2 | Escherichia coli | - |
- |
- |
| 7.6.2.2 | Haemophilus influenzae | - |
- |
- |
| 7.6.2.2 | Helicobacter pylori | - |
- |
- |
| 7.6.2.2 | Homo sapiens | - |
- |
- |
| 7.6.2.2 | Lactococcus lactis | - |
- |
- |
| 7.6.2.2 | Leishmania donovani | - |
- |
- |
| 7.6.2.2 | Leishmania tarentolae | - |
- |
- |
| 7.6.2.2 | Levilactobacillus brevis | - |
- |
- |
| 7.6.2.2 | Mycoplasma genitalium | - |
- |
- |
| 7.6.2.2 | Plasmodium falciparum | - |
- |
- |
| 7.6.2.2 | Saccharomyces cerevisiae | - |
- |
- |
| 7.6.2.2 | Staphylococcus aureus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | RPMI-8226 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | additional information | overexpression of the multidrug resistance P-glycoprotein and the multidrug resistance-associated protein MRP1 is a principal cause of resistance of cancer to chemotherapy | Homo sapiens | ? | - |
? | |
| 7.6.2.2 | additional information | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | Entamoeba histolytica | ? | - |
? | |
| 7.6.2.2 | additional information | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | Leishmania donovani | ? | - |
? | |
| 7.6.2.2 | additional information | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | Candida albicans | ? | - |
? | |
| 7.6.2.2 | additional information | enzyme plays an important role in microbial resistance to neutral or positively charged amphiphilic drugs | Plasmodium falciparum | ? | - |
? | |
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