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Literature summary extracted from

  • Hosono, H.; Kuno, S.
    The purification and properties of cytidine deaminase from Escherichia coli (1973), J. Biochem., 74, 797-803.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.5 EDTA
-
Mus musculus
3.5.4.5 EDTA 10 mM, activity 108% Escherichia coli
3.5.4.5 iodoacetic acid 0.10 mM, activity 105% Escherichia coli
3.5.4.5 N-ethylmaleimide 0.10-0.20 mM, activity 114% Escherichia coli
3.5.4.5 p-chloromercuribenzoate 0.105 mM, activity 112% Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.5 5-bromodeoxyuridine 1.0 mM, 31% inhibition Escherichia coli
3.5.4.5 adenosine 4.0 mM, 22% inhibition Escherichia coli
3.5.4.5 Cu2+
-
Escherichia coli
3.5.4.5 Cu2+
-
Mus musculus
3.5.4.5 deoxyadenosine 3.0 mM, 32% inhibition Escherichia coli
3.5.4.5 deoxyguanosine 1.0 mM, 13% inhibition Escherichia coli
3.5.4.5 deoxyuridine 1.0 mM, 32% inhibition Escherichia coli
3.5.4.5 dTTP
-
Mus musculus
3.5.4.5 dTTP
-
Ovis aries
3.5.4.5 dTTP 0.400 mM 50% inhibition Saccharomyces cerevisiae
3.5.4.5 dUTP
-
Mus musculus
3.5.4.5 dUTP
-
Ovis aries
3.5.4.5 Fe2+
-
Escherichia coli
3.5.4.5 Fe3+
-
Escherichia coli
3.5.4.5 guanosine 1.0 mM, 4% inhibition Escherichia coli
3.5.4.5 Hg+
-
Escherichia coli
3.5.4.5 Hg+
-
Mus musculus
3.5.4.5 mercaptoethanol
-
Escherichia coli
3.5.4.5 Mersalyl acid
-
Escherichia coli
3.5.4.5 Mersalyl acid
-
Mus musculus
3.5.4.5 Mersalyl acid
-
Saccharomyces cerevisiae
3.5.4.5 thymidine 1.0 mM, 21% inhibition Escherichia coli
3.5.4.5 uracil arabinoside 4.0 mM, 48% inhibition Escherichia coli
3.5.4.5 Urea above 2 M, reversible inactivation Escherichia coli
3.5.4.5 uridine 4.0 mM, 20% inhibition Escherichia coli
3.5.4.5 Zn2+ above 10 mM Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.5 0.06
-
5-Methyldeoxycytidine
-
Escherichia coli
3.5.4.5 0.0853
-
deoxycytidine
-
Escherichia coli
3.5.4.5 0.087
-
5'-fluoro-5'-deoxycytidine
-
Escherichia coli
3.5.4.5 0.167
-
cytidine
-
Escherichia coli
3.5.4.5 0.26
-
cytosine arabinoside
-
Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.4.5 Mg2+ 1 mM, activity 101% Escherichia coli
3.5.4.5 Mn2+
-
Mus musculus
3.5.4.5 Mn2+ 10 mM, activity 106% Escherichia coli
3.5.4.5 Zn2+ 1 mM, activity 103% Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.5 54000
-
gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.5 cytidine + H2O Mus musculus
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Escherichia coli
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Saccharomyces cerevisiae
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Ovis aries
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Bacillus cereus
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Mus musculus BALB/c
-
uridine + NH3
-
?
3.5.4.5 cytidine + H2O Escherichia coli Y-70-272
-
uridine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.5 Bacillus cereus
-
-
-
3.5.4.5 Escherichia coli
-
-
-
3.5.4.5 Escherichia coli Y-70-272
-
-
-
3.5.4.5 Mus musculus
-
mouse
-
3.5.4.5 Mus musculus
-
BALB/c
-
3.5.4.5 Mus musculus BALB/c
-
BALB/c
-
3.5.4.5 Ovis aries
-
-
-
3.5.4.5 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.5
-
Escherichia coli

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.5 liver
-
Mus musculus
-
3.5.4.5 liver
-
Ovis aries
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.5 9.53
-
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.5 5'-fluoro-5'-deoxycytidine + H2O
-
Escherichia coli 5'-fluoro-5'-deoxyuridine + NH3
-
?
3.5.4.5 5'-fluoro-5'-deoxycytidine + H2O
-
Escherichia coli Y-70-272 5'-fluoro-5'-deoxyuridine + NH3
-
?
3.5.4.5 5'-methyl-2'-deoxycytidine + H2O
-
Mus musculus 5'-methyl-2-deoxyuridine + NH3
-
?
3.5.4.5 5'-methyl-2'-deoxycytidine + H2O
-
Escherichia coli 5'-methyl-2-deoxyuridine + NH3
-
?
3.5.4.5 5'-methyl-2'-deoxycytidine + H2O
-
Mus musculus BALB/c 5'-methyl-2-deoxyuridine + NH3
-
?
3.5.4.5 5-methyldeoxycytidine + H2O
-
Escherichia coli ?
-
?
3.5.4.5 cytidine + H2O
-
Mus musculus uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Escherichia coli uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Saccharomyces cerevisiae uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Ovis aries uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Bacillus cereus uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Mus musculus BALB/c uridine + NH3
-
?
3.5.4.5 cytidine + H2O
-
Escherichia coli Y-70-272 uridine + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Mus musculus uridine arabinoside + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Escherichia coli uridine arabinoside + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Mus musculus BALB/c uridine arabinoside + NH3
-
?
3.5.4.5 cytosine arabinoside + H2O
-
Escherichia coli Y-70-272 uridine arabinoside + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Mus musculus deoxyuridine + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Escherichia coli deoxyuridine + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Mus musculus BALB/c deoxyuridine + NH3
-
?
3.5.4.5 deoxycytidine + H2O
-
Escherichia coli Y-70-272 deoxyuridine + NH3
-
?
3.5.4.5 additional information cytosine and cytidine nucleosides are not deaminated by this enzyme Escherichia coli ?
-
?
3.5.4.5 additional information cytosine and cytidine nucleosides are not deaminated by this enzyme Escherichia coli Y-70-272 ?
-
?

Subunits

EC Number Subunits Comment Organism
3.5.4.5 monomer 1 * 54000 Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
3.5.4.5 mammalian deminase
-
Mus musculus
3.5.4.5 mammalian deminase
-
Ovis aries
3.5.4.5 yeast cytidine deaminase
-
Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.5 6 7.5
-
Escherichia coli