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Literature summary extracted from

  • Weisberg, E.P.; O'Donnell, J.M.
    Purification and characterization of GTP cyclohydrolase I from Drosophila melanogaster (1986), J. Biol. Chem., 261, 1453-1458.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.5.4.16 bovine serum albumin stabilizes Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.16 ATP
-
Drosophila melanogaster
3.5.4.16 Ca2+
-
Drosophila melanogaster
3.5.4.16 divalent cations
-
Drosophila melanogaster
3.5.4.16 GTP substrate inhibition above 0.2 mM Drosophila melanogaster
3.5.4.16 ITP
-
Drosophila melanogaster
3.5.4.16 KCl
-
Drosophila melanogaster
3.5.4.16 Mg2+
-
Drosophila melanogaster
3.5.4.16 Mn2+
-
Drosophila melanogaster
3.5.4.16 NaCl
-
Drosophila melanogaster

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.4.16 39000
-
x * 39000, SDS-PAGE Drosophila melanogaster
3.5.4.16 575000
-
gel filtration Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.16 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.16
-
Drosophila melanogaster

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.4.16 additional information
-
-
Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.16 GTP + H2O
-
Drosophila melanogaster formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
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Subunits

EC Number Subunits Comment Organism
3.5.4.16 polymer x * 39000, SDS-PAGE Drosophila melanogaster

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.4.16 60
-
-
Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.4.16 7.3
-
phosphate buffer: 2 optima, pH 7.3 and 8.0 Drosophila melanogaster
3.5.4.16 8
-
phosphate buffer: 2 optima, pH 7.3 and 8.0 Drosophila melanogaster