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Literature summary extracted from

  • Erbs, P.; Exinger, F.; Jund, R.
    Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans (1997), Curr. Genet., 31, 1-6.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.4.1 medicine
-
 Escherichia coli
3.5.4.1 medicine facilitate pharmacological advance, possible application is transfer of FCY1 and FCA1 to mammalian cells naturally lacking enzyme activity, these genes should confer lethal sensitivity to 5-fluorocytosine Saccharomyces cerevisiae
3.5.4.1 medicine facilitate pharmacological advance, possible application is transfer of FCY1 and FCA1 to mammalian cells naturally lacking enzyme activity, these genes should confer lethal sensitivity to 5-fluorocytosine Candida albicans

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.4.1 codBA operon encoding cytosine permease and cytosine deaminase cloned Escherichia coli
3.5.4.1 FCA1 gene cloned from a genomic Candida albicans gene bank, constructed in the low-copy vector pMK122 Candida albicans
3.5.4.1 FCY1 gene cloned and characterized Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.1 cytosine + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O Escherichia coli
-
 uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O Saccharomyces cerevisiae
-
 uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O Candida albicans
-
 uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O Aspergillus fumigatus
-
 uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O Aspergillus fumigatus IFO5840
-
 uracil + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.1 Aspergillus fumigatus
-
 IFO5840
-
3.5.4.1 Aspergillus fumigatus IFO5840
-
 IFO5840
-
3.5.4.1 Candida albicans
-
-
-
3.5.4.1 Escherichia coli
-
-
-
3.5.4.1 Saccharomyces cerevisiae
-
-
-
3.5.4.1 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.1 cytosine + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O
-
 Escherichia coli uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O
-
 Saccharomyces cerevisiae uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O
-
 Candida albicans uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O
-
 Aspergillus fumigatus uracil + NH3
-
 ?
3.5.4.1 cytosine + H2O
-
 Aspergillus fumigatus IFO5840 uracil + NH3
-
 ?