Literature summary extracted from

Van Der Werf, P.; Stephani, R.A.; Meister, A.
Accumulation of 5-oxoproline in mouse tissues after inhibition of 5-oxoprolinase and administration of amino acids: Evidence for function of the gamma-glutamyl cycle (1974), Proc. Natl. Acad. Sci. USA, 71, 1026-1029.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.5.2.9	L-2-imidazolidone-4-carboxylate	-	Mus musculus
3.5.2.9	L-2-imidazolidone-4-carboxylate	-	Rattus norvegicus
3.5.2.9	L-dihydroorotic acid	-	Mus musculus
3.5.2.9	L-dihydroorotic acid	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.5.2.9	5-oxo-L-proline + H2O + ATP	Mus musculus	-	L-glutamate + ADP + phosphate	-	?
3.5.2.9	5-oxo-L-proline + H2O + ATP	Homo sapiens	-	L-glutamate + ADP + phosphate	-	?
3.5.2.9	5-oxo-L-proline + H2O + ATP	Rattus norvegicus	-	L-glutamate + ADP + phosphate	-	?
3.5.2.9	5-oxo-L-proline + H2O + ATP	Pseudomonas sp.	-	L-glutamate + ADP + phosphate	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.5.2.9	Homo sapiens	-	human	-
3.5.2.9	Mus musculus	-	-	-
3.5.2.9	Pseudomonas sp.	-	-	-
3.5.2.9	Rattus norvegicus	-	rat	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.5.2.9	-	Rattus norvegicus
3.5.2.9	-	Pseudomonas sp.

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.5.2.9	brain	-	Mus musculus	-
3.5.2.9	brain	-	Homo sapiens	-
3.5.2.9	brain	-	Rattus norvegicus	-
3.5.2.9	choroid plexus	-	Mus musculus	-
3.5.2.9	choroid plexus	-	Rattus norvegicus	-
3.5.2.9	eye	-	Mus musculus	-
3.5.2.9	fibroblast	-	Homo sapiens	-
3.5.2.9	kidney	-	Mus musculus	-
3.5.2.9	kidney	-	Homo sapiens	-
3.5.2.9	kidney	-	Rattus norvegicus	-
3.5.2.9	liver	-	Mus musculus	-
3.5.2.9	liver	-	Homo sapiens	-
3.5.2.9	liver	-	Rattus norvegicus	-
3.5.2.9	skin	-	Mus musculus	-
3.5.2.9	skin	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.5.2.9	5-oxo-L-proline + H2O + ATP	-	Mus musculus	L-glutamate + ADP + phosphate	-	?
3.5.2.9	5-oxo-L-proline + H2O + ATP	-	Homo sapiens	L-glutamate + ADP + phosphate	-	?
3.5.2.9	5-oxo-L-proline + H2O + ATP	-	Rattus norvegicus	L-glutamate + ADP + phosphate	-	?
3.5.2.9	5-oxo-L-proline + H2O + ATP	-	Pseudomonas sp.	L-glutamate + ADP + phosphate	-	?

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Release 2023.1 (January 2023)