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Literature summary extracted from

  • Moore, G.P.; Sullivan, D.T.
    The characterization of multiple forms of kynurenine formidase in Drosophila melanogaster (1975), Biochim. Biophys. Acta, 397, 468-477.
    View publication on PubMed

General Stability

EC Number General Stability Organism
3.5.1.9 formamidase I more heat-stable than formamidase II Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.9 0.83
-
 N-formyl-L-kynurenine formamidase II Drosophila melanogaster
3.5.1.9 5
-
 N-formyl-L-kynurenine formamidase I Drosophila melanogaster

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.9 30500
-
 formamidase II, gel filtration Lithobates pipiens
3.5.1.9 31000
-
 formamidase II, gel filtration Drosophila melanogaster
3.5.1.9 36000
-
 formamidase II, gel filtration Mus musculus
3.5.1.9 36500
-
 formamidase II, gel filtration Drosophila virilis
3.5.1.9 58500
-
 formamidase I, gel filtration Saccharomyces cerevisiae
3.5.1.9 59000
-
 formamidase I, gel filtration Gallus gallus
3.5.1.9 59000
-
 formamidase I, gel filtration Bos taurus
3.5.1.9 60000
-
-
 Gallus gallus
3.5.1.9 60000
-
 formamidase I, gel filtration Drosophila melanogaster
3.5.1.9 60000
-
 formamidase I, gel filtration Musca domestica
3.5.1.9 60000
-
 formamidase I, gel filtration Drosophila virilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.9 N-formyl-L-kynurenine + H2O Gallus gallus
-
 L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O Drosophila melanogaster
-
 L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O Saccharomyces cerevisiae
-
 L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O Bos taurus
-
 L-kynurenine + formate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.9 Bos taurus
-
 formamidase I
-
3.5.1.9 Drosophila melanogaster
-
 2 forms, formamidase I and II
-
3.5.1.9 Drosophila virilis
-
 2 forms, formamidase I and II
-
3.5.1.9 Gallus gallus
-
 chicken, formamidase I
-
3.5.1.9 Lithobates pipiens
-
 frog, formamidase II
-
3.5.1.9 Mus musculus
-
 formamidase II
-
3.5.1.9 Musca domestica
-
 housefly, formamidase I
-
3.5.1.9 Saccharomyces cerevisiae
-
 1 form, formamidase I
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.9 to homogeneity, chromatography techniques, 2 forms Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.9 cell culture
-
 Saccharomyces cerevisiae
-
3.5.1.9 liver
-
 Gallus gallus
-
3.5.1.9 liver
-
 Mus musculus
-
3.5.1.9 liver
-
 Bos taurus
-
3.5.1.9 liver
-
 Lithobates pipiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.9 0.26
-
 formamidase I Drosophila melanogaster
3.5.1.9 0.48
-
 formamidase II Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.9 N-formyl-L-kynurenine + H2O
-
 Gallus gallus L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O
-
 Drosophila melanogaster L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O
-
 Saccharomyces cerevisiae L-kynurenine + formate
-
 ?
3.5.1.9 N-formyl-L-kynurenine + H2O
-
 Bos taurus L-kynurenine + formate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.9 6.5 8 formamidase II Drosophila melanogaster
3.5.1.9 6.7 7.8 formamidase I Drosophila melanogaster