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Literature summary extracted from

  • Goldstein, F.B.
    Amidohydrolases of brain; enzymatic hydrolysis of N-acetyl-L-aspartate and other N-acyl-L-amino acids (1976), J. Neurochem., 26, 45-49.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.1.15 chloroacetylamino acids
-
 Mus musculus
3.5.1.15 chloroacetylamino acids
-
 Rattus norvegicus
3.5.1.15 chloroacetylamino acids
-
 Sus scrofa
3.5.1.15 chloroacetylamino acids
-
 Bos taurus
3.5.1.15 chloroacetylamino acids
-
 Oryctolagus cuniculus
3.5.1.15 chloroacetylamino acids
-
 Mesocricetus auratus
3.5.1.15 chloroacetylamino acids
-
 Felis catus
3.5.1.15 chloroacetylamino acids
-
 Macaca mulatta
3.5.1.15 chloroacetylamino acids
-
 Columba sp.
3.5.1.15 chloroacetylamino acids
-
 Macaca iris
3.5.1.15 Triton X-100 increases activity of the enzyme Mus musculus
3.5.1.15 Triton X-100 increases activity of the enzyme Rattus norvegicus
3.5.1.15 Triton X-100 increases activity of the enzyme Sus scrofa
3.5.1.15 Triton X-100 increases activity of the enzyme Bos taurus
3.5.1.15 Triton X-100 increases activity of the enzyme Oryctolagus cuniculus
3.5.1.15 Triton X-100 increases activity of the enzyme Mesocricetus auratus
3.5.1.15 Triton X-100 increases activity of the enzyme Felis catus
3.5.1.15 Triton X-100 increases activity of the enzyme Macaca mulatta
3.5.1.15 Triton X-100 increases activity of the enzyme Columba sp.
3.5.1.15 Triton X-100 increases activity of the enzyme Macaca iris

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.15 0.2
-
 N-acyl L-aspartic acid
-
 Sus scrofa
3.5.1.15 0.2
-
 N-acyl L-aspartic acid brain enzyme Rattus norvegicus
3.5.1.15 5.1
-
 N-acyl-L-aspartic acid
-
 Macaca mulatta

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.15 N-acetyl-L-aspartic acid + H2O Mus musculus
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Rattus norvegicus
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Sus scrofa
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Bos taurus
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Oryctolagus cuniculus
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Mesocricetus auratus
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Felis catus
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Macaca mulatta
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Columba sp.
-
 acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O Macaca iris
-
 acetate + aspartic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.15 Bos taurus
-
 bovine
-
3.5.1.15 Columba sp.
-
 pigeon
-
3.5.1.15 Felis catus
-
 cat
-
3.5.1.15 Macaca iris
-
 java monkey
-
3.5.1.15 Macaca mulatta
-
 rhesus monkey
-
3.5.1.15 Mesocricetus auratus
-
 hamster
-
3.5.1.15 Mus musculus
-
 mouse
-
3.5.1.15 no activity in Cavia porcellus
-
 male albino
-
3.5.1.15 Oryctolagus cuniculus
-
 rabbit
-
3.5.1.15 Rattus norvegicus
-
-
-
3.5.1.15 Rattus norvegicus Sprague Dawley
-
-
-
3.5.1.15 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.15 partial Macaca mulatta

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.15 brain
-
 Mus musculus
-
3.5.1.15 brain
-
 Rattus norvegicus
-
3.5.1.15 brain
-
 Sus scrofa
-
3.5.1.15 brain
-
 Bos taurus
-
3.5.1.15 brain
-
 Oryctolagus cuniculus
-
3.5.1.15 brain
-
 Mesocricetus auratus
-
3.5.1.15 brain
-
 Felis catus
-
3.5.1.15 brain
-
 Macaca mulatta
-
3.5.1.15 brain
-
 Columba sp.
-
3.5.1.15 brain
-
 Macaca iris
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.5.1.15 0.25
-
-
 Columba sp.
3.5.1.15 0.29
-
-
 Mesocricetus auratus
3.5.1.15 0.3
-
-
 Oryctolagus cuniculus
3.5.1.15 0.42
-
-
 Rattus norvegicus
3.5.1.15 0.45
-
-
 Mus musculus
3.5.1.15 0.98
-
-
 Macaca mulatta

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.15 acetyl-DL-alanine + H2O
-
 Rattus norvegicus acetate + DL-alanine
-
 ?
3.5.1.15 acetyl-DL-alanine + H2O
-
 Rattus norvegicus Sprague Dawley acetate + DL-alanine
-
 ?
3.5.1.15 acetyl-DL-methionine + H2O
-
 Rattus norvegicus acetate + methionine
-
 ?
3.5.1.15 acetyl-DL-methionine + H2O
-
 Sus scrofa acetate + methionine
-
 ?
3.5.1.15 acetyl-DL-methionine + H2O
-
 Rattus norvegicus Sprague Dawley acetate + methionine
-
 ?
3.5.1.15 acetyl-L-glutamate + H2O
-
 Rattus norvegicus acetate + glutamate
-
 ?
3.5.1.15 acetyl-L-glutamate + H2O
-
 Rattus norvegicus Sprague Dawley acetate + glutamate
-
 ?
3.5.1.15 acetyl-L-leucine + H2O
-
 Rattus norvegicus acetate + leucine
-
 ?
3.5.1.15 acetyl-L-leucine + H2O
-
 Rattus norvegicus Sprague Dawley acetate + leucine
-
 ?
3.5.1.15 chloroacetyl-DL-alanine + H2O
-
 Rattus norvegicus chloroacetate + DL-alanine
-
 ?
3.5.1.15 chloroacetyl-DL-alanine + H2O
-
 Sus scrofa chloroacetate + DL-alanine
-
 ?
3.5.1.15 chloroacetyl-DL-norleucine + H2O
-
 Rattus norvegicus chloroacetate + DL-norleucine
-
 ?
3.5.1.15 chloroacetyl-L-aspartate + H2O
-
 Rattus norvegicus chloroacetate + L-aspartate
-
 ?
3.5.1.15 chloroacetyl-L-aspartate + H2O
-
 Sus scrofa chloroacetate + L-aspartate
-
 ?
3.5.1.15 chloroacetyl-L-leucine + H2O
-
 Rattus norvegicus chloroacetate + L-leucine
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Mus musculus acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Rattus norvegicus acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Sus scrofa acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Bos taurus acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Oryctolagus cuniculus acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Mesocricetus auratus acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Felis catus acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Macaca mulatta acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Columba sp. acetate + aspartic acid
-
 ?
3.5.1.15 N-acetyl-L-aspartic acid + H2O
-
 Macaca iris acetate + aspartic acid
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Mus musculus acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Rattus norvegicus acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Sus scrofa acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Bos taurus acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Oryctolagus cuniculus acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Mesocricetus auratus acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Felis catus acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Macaca mulatta acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Columba sp. acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Macaca iris acetate + L-aspartate
-
 ?
3.5.1.15 N-acyl L-aspartic acid + H2O
-
 Rattus norvegicus Sprague Dawley acetate + L-aspartate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.15 8.5
-
 N-acetyl-L-aspartate as substrate Macaca mulatta