Any feedback?
Literature summary extracted from
- Characteristics of a cytosolic arylacylamidase metabolizing thiacetazone (1991), J. Pharmacol. Exp. Ther., 262, 1225-1231.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.13 | Acetylsalicylic acid | - |
Rattus norvegicus |  |
| 3.5.1.13 | Ag+ | 1.0 mM AgNO3, marked inhibition | Rattus norvegicus | |
| 3.5.1.13 | Cu2+ | 0.5 mM CuSO4, marked inhibition | Rattus norvegicus | |
| 3.5.1.13 | eserine | - |
Homo sapiens | |
| 3.5.1.13 | eserine | - |
Rattus norvegicus | |
| 3.5.1.13 | malathion | 0.06 mM, 75% loss of activity | Rattus norvegicus | |
| 3.5.1.13 | PCMB | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.1.13 | 1.42 | - |
4-acetylaminobenzaldehyde thiosemicarbazone | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.5.1.13 | cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.1.13 | KI | activates | Rattus norvegicus | |
| 3.5.1.13 | NaI | activates | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.1.13 | Felis catus | - |
- |
- |
| 3.5.1.13 | Homo sapiens | - |
- |
- |
| 3.5.1.13 | Mus musculus | - |
- |
- |
| 3.5.1.13 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.1.13 | kidney | - |
Rattus norvegicus | - |
| 3.5.1.13 | liver | - |
Homo sapiens | - |
| 3.5.1.13 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.1.13 | 4-acetylaminobenzaldehyde thiosemicarbazone + H2O | i.e. thiacetazone | Rattus norvegicus | 4-aminobenzaldehyde thiosemicarbazone + acetic acid | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.13 | 6 | 9 | - |
Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.1.13 | 5.5 | 10 | pH 5.5: about 50% of maximal activity, pH 10.0: about 80% of maximal activity | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
