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Literature summary extracted from
- Racemization of alanine by the alanine racemase from Salmonella typhimurium and Bacillus stearothermophilus: energetic reaction profiles (1988), Biochemistry, 27, 3267-3276.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.1 | 0.5 | - |
D-Ala | alr gene encoded | Salmonella enterica subsp. enterica serovar Typhimurium |  |
| 5.1.1.1 | 1.7 | - |
L-Ala | alr gene encoded | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5.1.1.1 | 2.2 | - |
D-Ala | D-Ala, dadB encoded enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5.1.1.1 | 2.7 | - |
L-Ala | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5.1.1.1 | 2.7 | - |
L-Ala | D-Ala | Geobacillus stearothermophilus | |
| 5.1.1.1 | 4.4 | - |
L-Ala | - |
Geobacillus stearothermophilus | |
| 5.1.1.1 | 11 | - |
L-Ala | dadB gene encoded | Salmonella enterica subsp. enterica serovar Typhimurium | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.1 | L-Ala | Salmonella enterica subsp. enterica serovar Typhimurium | enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall | ? | - |
? | |
| 5.1.1.1 | L-Ala | Geobacillus stearothermophilus | enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.1.1.1 | Geobacillus stearothermophilus | - |
- |
- |
| 5.1.1.1 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
encoded by the dadB and alr gene | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.1.1.1 | L-Ala | - |
Salmonella enterica subsp. enterica serovar Typhimurium | D-Ala | - |
? | |
| 5.1.1.1 | L-Ala | - |
Geobacillus stearothermophilus | D-Ala | - |
? | |
| 5.1.1.1 | L-Ala | enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| 5.1.1.1 | L-Ala | enzyme provides D-Ala as an essential building block for biosynthesis of the peptidoglycan layer of the cell wall | Geobacillus stearothermophilus | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.1.1.1 | 1.1 | - |
L-Ala | - |
Geobacillus stearothermophilus | |
| 5.1.1.1 | 1.6 | - |
D-Ala | dadB encoded enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5.1.1.1 | 2.6 | - |
D-Ala | alr encoded enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5.1.1.1 | 7 | - |
D-Ala | - |
Geobacillus stearothermophilus | |
| 5.1.1.1 | 7.3 | - |
L-Ala | dadB encoded enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5.1.1.1 | 9.7 | - |
L-Ala | alr encoded enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.1.1.1 | pyridoxal 5'-phosphate | pyridoxal 5'-phosphate dependent enzyme | Salmonella enterica subsp. enterica serovar Typhimurium | |
| 5.1.1.1 | pyridoxal 5'-phosphate | pyridoxal 5'-phosphate dependent enzyme | Geobacillus stearothermophilus | |
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