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Literature summary extracted from
- Specific and reversible inhibition of the blunt end joining activity of the T4 DNA ligase (1981), Nucleic Acids Res., 9, 3695-3705.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.5.1.1 | ATP | 5 mM and higher. 5 mM, completely inhibits blunt end ligation, only 8% reduces ligation of cohesive DNA ends | Tequatrovirus T4 |  |
| 6.5.1.1 | spermidine | 10 mM, inhibits joining of DNA blunt ends, no effect on the joining of cohesive termini | Tequatrovirus T4 | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.5.1.1 | Tequatrovirus T4 | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.5.1.1 | ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Tequatrovirus T4 | AMP + diphosphate + (deoxyribonucleotide)n+m | - |
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