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Literature summary extracted from

  • Ahmad, F.; Ahmad, P.M.; Mendez, A.
    Rat liver pyruvate carboxylase. Purification, detection and quantification of apo and holo forms by immuno-blotting and by an enzyme-linked immunosorbent assay (1986), Biochem. J., 236, 527-533.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.1 mitochondrion
-
 Homo sapiens 5739
-
6.4.1.1 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.4.1.1 ATP + pyruvate + HCO3- Mammalia the enzyme occupies a strategic position in the intermediary metabolism of numerous tissues. In the gluconeogenic tissues, e.g. liver, kidney, it catalyzes the first step in the synthesis of glucose from pyruvate. During lipogenesis in liver, adipose tissue and mammary gland it participates in the synthesis of acetyl groups and reducing groups for transport from the mitochondria to the cytosol. In yet other tissues it fulfills an anaplerotic function ?
-
 ?
6.4.1.1 ATP + pyruvate + HCO3- Homo sapiens pyruvate carboxylase deficiency in humans causes severe acidosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.1 Homo sapiens
-
-
-
6.4.1.1 Mammalia
-
-
-
6.4.1.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.4.1.1
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.1 liver
-
 Homo sapiens
-
6.4.1.1 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.4.1.1 34
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.4.1.1 ATP + pyruvate + HCO3-
-
 Mammalia ADP + phosphate + oxaloacetate
-
 ?
6.4.1.1 ATP + pyruvate + HCO3-
-
 Homo sapiens ADP + phosphate + oxaloacetate
-
 ?
6.4.1.1 ATP + pyruvate + HCO3-
-
 Rattus norvegicus ADP + phosphate + oxaloacetate
-
 ?
6.4.1.1 ATP + pyruvate + HCO3- the enzyme occupies a strategic position in the intermediary metabolism of numerous tissues. In the gluconeogenic tissues, e.g. liver, kidney, it catalyzes the first step in the synthesis of glucose from pyruvate. During lipogenesis in liver, adipose tissue and mammary gland it participates in the synthesis of acetyl groups and reducing groups for transport from the mitochondria to the cytosol. In yet other tissues it fulfills an anaplerotic function Mammalia ?
-
 ?
6.4.1.1 ATP + pyruvate + HCO3- pyruvate carboxylase deficiency in humans causes severe acidosis Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.4.1.1 ?
-
 Homo sapiens
6.4.1.1 ? x * 125000-130000, SDS-PAGE with dithiothreitol Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.1 biotin enzyme contains biotin Homo sapiens
6.4.1.1 biotin enzyme contains biotin Rattus norvegicus