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Literature summary extracted from

  • Santacroce, M.J.; Blankenship, J.
    Inhibition of acetylspermidine deacetylating activity from rat liver (1982), Proc. West. Pharmacol. Soc., 25, 113-118.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.48 1,4-diaminobutane Ki: 1.45 mM; putrescine Rattus sp.
3.5.1.48 1,5-Diaminopentane cadaverine; Ki: 1.5 mM Rattus sp.
3.5.1.48 1,6-diaminohexane Ki: 1.5 mM Rattus sp.
3.5.1.48 acetylprocainamide Ki: 1.9 mM Rattus sp.
3.5.1.48 N1-acetylspermidine Ki: 0.16 mM, competitive inhibition Rattus sp.
3.5.1.48 spermidine Ki: 0.31 mM Rattus sp.
3.5.1.48 spermine Ki: 1.15 mM Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.48 0.004
-
 N8-Acetylspermidine
-
 Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.48 cytosol
-
 Rattus sp. 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.48 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.48 liver
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.48 N8-acetylspermidine + H2O involvement in controlling the levels of polyamines and acetylated polyamines in tissues Rattus sp. acetate + spermidine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.48 0.31
-
 spermidine
-
 Rattus sp.
3.5.1.48 1.15
-
 spermine
-
 Rattus sp.
3.5.1.48 1.45
-
 1,4-diaminobutane
-
 Rattus sp.
3.5.1.48 1.5
-
 1,6-diaminohexane
-
 Rattus sp.
3.5.1.48 1.5
-
 1,5-Diaminopentane
-
 Rattus sp.
3.5.1.48 1.9
-
 acetylprocainamide
-
 Rattus sp.