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Literature summary extracted from

  • Huang, T.L.; Dredar, S.A.; Manneh, V.A.; Blankenship, J.W.; Fries, D.S.
    Inhibition of N8-acetylspermidine deacetylase by active-site-directed metal coordination inhibitiors (1992), J. Med. Chem., 35, 2414-2418.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.48 1,10-phenanthroline Ki: 1.3 mM Rattus sp.
3.5.1.48 2,2'-dipyridyl Ki: 1.9 mM Rattus sp.
3.5.1.48 3-[(3-aminopropyl)amino]-N-hydroxyhexanamide non-competitive inhibition, Ki: 1 nM Rattus sp.
3.5.1.48 6-aminohexanoic acid Ki: 0.05 mM Rattus sp.
3.5.1.48 6-[(3-aminopropyl)amino]hexanoic acid Ki: 0.011 mM Rattus sp.
3.5.1.48 diisopropyl fluorophosphate weak inhibition, Ki: 33 mM Rattus sp.
3.5.1.48 EDTA Ki: 3.5 mM Rattus sp.
3.5.1.48 N-ethylmaleimide Ki: 0.86 mM Rattus sp.
3.5.1.48 p-chloromercuribenzoic acid Ki: 0.15 mM Rattus sp.
3.5.1.48 sodium butyrate weak inhibition, Ki: 38.5 mM Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.48 0.011
-
 N8-Acetylspermidine
-
 Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.48 cytosol
-
 Rattus sp. 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.48 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.48 N8-acetylspermidine + H2O involvement in cell growth and differentiation Rattus sp. acetate + spermidine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.1.48 0.000001
-
 3-[(3-aminopropyl)amino]-N-hydroxyhexanamide non-competitive inhibition Rattus sp.
3.5.1.48 0.011
-
 6-[(3-aminopropyl)amino]hexanoic acid
-
 Rattus sp.
3.5.1.48 0.05
-
 6-aminohexanoic acid
-
 Rattus sp.
3.5.1.48 0.15
-
 p-chloromercuribenzoic acid
-
 Rattus sp.
3.5.1.48 1.3
-
 1,10-phenanthroline
-
 Rattus sp.
3.5.1.48 1.9
-
 2,2'-dipyridyl
-
 Rattus sp.
3.5.1.48 3.5
-
 EDTA
-
 Rattus sp.
3.5.1.48 33
-
 diisopropyl fluorophosphate weak inhibition Rattus sp.
3.5.1.48 38.5
-
 sodium butyrate weak inhibition Rattus sp.