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Literature summary extracted from

  • Snyder, F.; Lee, T.C.; Blank, M.L.
    The role of transacylases in the metabolism of arachidonate and platelet activating factor (1992), Prog. Lipid Res., 31, 65-86.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.148 Zn2+ strong Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.148 0.0015
-
 1-hexadecyl-2-lyso-glycerophosphocholine
-
 Oryctolagus cuniculus
2.3.1.148 0.0038
-
 1-acyl-2-lyso-glycerophosphocholine
-
 Oryctolagus cuniculus
2.3.1.148 0.017
-
 1-palmitoyl-2-lyso-glycerophosphocholine
-
 Rattus norvegicus
2.3.1.148 0.076
-
 lyso-phosphatidylserine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.148 microsome
-
 Rattus norvegicus
-
-
2.3.1.148 microsome
-
 Oryctolagus cuniculus
-
-
2.3.1.148 microsome
-
 Canis lupus familiaris
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.148 Canis lupus familiaris
-
-
-
2.3.1.148 Homo sapiens
-
-
-
2.3.1.148 Mus musculus
-
-
-
2.3.1.148 Oryctolagus cuniculus
-
-
-
2.3.1.148 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.148 alveolar macrophage
-
 Oryctolagus cuniculus
-
2.3.1.148 heart
-
 Canis lupus familiaris
-
2.3.1.148 liver
-
 Rattus norvegicus
-
2.3.1.148 liver
-
 Oryctolagus cuniculus
-
2.3.1.148 lung
-
 Rattus norvegicus
-
2.3.1.148 lymphocyte
-
 Mus musculus
-
2.3.1.148 macrophage
-
 Mus musculus
-
2.3.1.148 platelet
-
 Homo sapiens
-
2.3.1.148 platelet
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.148 1-Acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine transfer of arachidonate occurs through a bidirectional movement Mus musculus 1-Acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine
-
 ?
2.3.1.148 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + lyso-phosphatidylcholine
-
 Mus musculus 1-acyl-2-lyso-sn-glycero-3-phosphoinositol + ?
-
 ?
2.3.1.148 1-Acyl-2-arachidonoyl-sn-glycero-3-phosphophoinositol + lyso-phosphatidylethanolamine unidirectional transfer process of arachidonate Mus musculus 1-Acyl-2-lyso-sn-glycero-3-phosphoinositol + arachidonoylphosphatidylethanolamine
-
 ?
2.3.1.148 1-acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine
-
 Oryctolagus cuniculus 1-acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine
-
 r
2.3.1.148 1-Hexadecyl-2-lyso-glycerophosphocholine + phospholipid
-
 Oryctolagus cuniculus ?
-
 ?
2.3.1.148 1-palmitoyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine
-
 Rattus norvegicus 1-palmitoyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine
-
 r
2.3.1.148 lyso-Pasmenylethanolamine + phospholipid
-
 Homo sapiens ?
-
 ?
2.3.1.148 lyso-Phosphatidylethanolamine + phospholipid
-
 Homo sapiens Phosphatidylethanolamine + lyso-phospholipid
-
 ?
2.3.1.148 lyso-Phosphatidylinositol + phospholipid
-
 Homo sapiens Phosphatidylinositol + lyso-phospholipid
-
 ?
2.3.1.148 lyso-Phosphatidylserine + phospholipid
-
 Homo sapiens Phosphatidylserine + lyso-phospholipid
-
 ?
2.3.1.148 additional information arachidonate and linoleate at the sn-2 position of phosphatidylcholine can be transferred to lyso-phosphatidylethanolamine. The transfer of 16:0, 18:0, and 18:1 acyl moieties at the sn-2-position of phosphatidylcholine is negligible Rattus norvegicus ?
-
 ?
2.3.1.148 additional information more efficient transfer of arachidonate from phosphatidylcholine to the ethanolamine-containing phospholipids than from phosphatidylinositol Homo sapiens ?
-
 ?
2.3.1.148 Phosphatidylcholine + lyso-phosphatidylethanolamine
-
 Mus musculus lyso-Phosphatidylcholine + phosphatidylethanolamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.148 4.5
-
 bimodal pH-optimum, at pH 4.5 and at pH 7.5. The activity is 4-5times higher at pH 4.5 than at pH 7.5 Canis lupus familiaris
2.3.1.148 7.5
-
-
 Rattus norvegicus
2.3.1.148 7.5
-
 bimodal pH-optimum, at pH 7.5 and at pH 4.5 Canis lupus familiaris

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.148 CoA
-
 Canis lupus familiaris
2.3.1.148 CoA required Mus musculus
2.3.1.148 CoA required Homo sapiens
2.3.1.148 CoA required Rattus norvegicus
2.3.1.148 CoA required Oryctolagus cuniculus
2.3.1.148 CoA Km: 0.0015 mM, lung enzyme, with lyso-phosphatidylethanolamine as substrate Rattus norvegicus
2.3.1.148 CoA Km: 0.014 mM, liver enzyme, with 2-lyso-sn-phosphatidylinositol as substrate Rattus norvegicus
2.3.1.148 CoA Km: 0.0014 mM Homo sapiens
2.3.1.148 CoA Km: 0.0014 mM Oryctolagus cuniculus