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Literature summary extracted from

  • Reem, G.H.
    Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis (1968), J. Biol. Chem., 243, 5695-5701.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.7 ribose 5-phosphate inhibition above 0.0125 M Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.7 1.8
-
 5-O-phosphono-D-ribofuranose
-
 Gallus gallus
6.3.4.7 6.3
-
 NH4+
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.7 ATP + ribose 5-phosphate + NH4+ Gallus gallus alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine ?
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+ Pigeon alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine ?
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+ Anas platyrhynchos alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.7 Anas platyrhynchos
-
-
-
6.3.4.7 Gallus gallus
-
-
-
6.3.4.7 Pigeon
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.7 partial Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.7 liver
-
 Gallus gallus
-
6.3.4.7 liver
-
 Pigeon
-
6.3.4.7 liver
-
 Anas platyrhynchos
-

Storage Stability

EC Number Storage Stability Organism
6.3.4.7 -18°C, stable for several months Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.7 ATP + ribose 5-phosphate + Asn far less effective than NH4+ Gallus gallus ADP + phosphate + 5-phosphoribosylamine + Asp
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + Gln far less effective than NH4+ Gallus gallus ADP + phosphate + 5-phosphoribosylamine + Glu
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+
-
 Gallus gallus ADP + phosphate + 5-phosphoribosylamine
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+
-
 Pigeon ADP + phosphate + 5-phosphoribosylamine
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+
-
 Anas platyrhynchos ADP + phosphate + 5-phosphoribosylamine
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+ alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine Gallus gallus ?
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+ alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine Pigeon ?
-
 ?
6.3.4.7 ATP + ribose 5-phosphate + NH4+ alternate pathway to the reaction catalyzed by ribosyldiposphate 5'-phosphate amidotransferase, EC 2.4.2.14, for the enzymic formation of 5-phosphoribosylamine Anas platyrhynchos ?
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
6.3.4.7 80
-
 5 min, inactivation Gallus gallus