Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Stayton, M.M.; Rudolph, F.B.; Fromm, H.J.
    Regulation, genetics, and properties of adenylosuccinate synthetase (1983), Curr. Top. Cell. Regul., 22, 103-141.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.4 6-mercaptopurine riboside 5'-phosphate
-
 Escherichia coli
6.3.4.4 adenylosuccinate
-
 Escherichia coli
6.3.4.4 adenylosuccinate
-
 Homo sapiens
6.3.4.4 adenylosuccinate
-
 Oryctolagus cuniculus
6.3.4.4 adenylosuccinate
-
 Rattus norvegicus
6.3.4.4 beta,gamma-5'-Guanylylmethylene diphosphate
-
 Escherichia coli
6.3.4.4 fructose 1,6-diphosphate
-
 Oryctolagus cuniculus
6.3.4.4 fructose 1,6-diphosphate basic type M isozym more strongly inhibited than acidic type L isozym Rattus norvegicus
6.3.4.4 GDP
-
 Escherichia coli
6.3.4.4 GDP
-
 Homo sapiens
6.3.4.4 GDP
-
 Oryctolagus cuniculus
6.3.4.4 GDP
-
 Rattus norvegicus
6.3.4.4 Hadacidin
-
 Azotobacter vinelandii
6.3.4.4 Hadacidin
-
 Escherichia coli
6.3.4.4 Hadacidin
-
 Rattus norvegicus
6.3.4.4 additional information overview Azotobacter vinelandii
6.3.4.4 additional information overview Bacillus subtilis
6.3.4.4 additional information overview Escherichia coli
6.3.4.4 additional information overview Gallus gallus
6.3.4.4 additional information overview Homo sapiens
6.3.4.4 additional information overview Leishmania donovani
6.3.4.4 additional information overview Oryctolagus cuniculus
6.3.4.4 additional information overview Rattus norvegicus
6.3.4.4 additional information overview Schizosaccharomyces pombe
6.3.4.4 additional information overview Sus scrofa
6.3.4.4 additional information overview Triticum aestivum
6.3.4.4 additional information overview Trypanosoma cruzi
6.3.4.4 nucleotides acidic type L isozyme more strongly inhibited than basic type M isozyme Rattus norvegicus
6.3.4.4 succinate
-
 Azotobacter vinelandii
6.3.4.4 succinate
-
 Escherichia coli
6.3.4.4 succinate
-
 Homo sapiens
6.3.4.4 succinate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.4 0.004 0.38 GTP muscle enzyme Rattus norvegicus
6.3.4.4 0.01 0.048 GTP
-
 Escherichia coli
6.3.4.4 0.01 0.012 GTP
-
 Oryctolagus cuniculus
6.3.4.4 0.011
-
 GTP
-
 Sus scrofa
6.3.4.4 0.012
-
 GTP muscle enzyme Gallus gallus
6.3.4.4 0.012
-
 GTP IMP Leishmania donovani
6.3.4.4 0.013
-
 IMP
-
 Azotobacter vinelandii
6.3.4.4 0.015
-
 GTP
-
 Azotobacter vinelandii
6.3.4.4 0.015 0.13 GTP liver acidic type L isozyme Rattus norvegicus
6.3.4.4 0.017
-
 GTP liver enzyme Gallus gallus
6.3.4.4 0.018
-
 GTP heart enzyme Rattus norvegicus
6.3.4.4 0.02
-
 GTP
-
 Schizosaccharomyces pombe
6.3.4.4 0.02
-
 GTP Asp, liver enzyme Gallus gallus
6.3.4.4 0.02
-
 GTP IMP, liver enzyme Gallus gallus
6.3.4.4 0.02 0.2 IMP
-
 Escherichia coli
6.3.4.4 0.03
-
 Asp
-
 Escherichia coli
6.3.4.4 0.03
-
 Asp muscle enzyme Gallus gallus
6.3.4.4 0.03 0.32 IMP liver acidic type L isozyme Rattus norvegicus
6.3.4.4 0.031 0.072 GTP
-
 Homo sapiens
6.3.4.4 0.034
-
 IMP
-
 Azotobacter vinelandii
6.3.4.4 0.037 0.07 IMP
-
 Schizosaccharomyces pombe
6.3.4.4 0.047
-
 IMP
-
 Escherichia coli
6.3.4.4 0.073
-
 GTP
-
 Azotobacter vinelandii
6.3.4.4 0.09
-
 GTP IMP Triticum aestivum
6.3.4.4 0.09
-
 GTP liver basic type L isozyme Rattus norvegicus
6.3.4.4 0.107 0.2 IMP
-
 Oryctolagus cuniculus
6.3.4.4 0.167
-
 IMP heart enzyme Rattus norvegicus
6.3.4.4 0.171
-
 IMP muscle enzyme Gallus gallus
6.3.4.4 0.2
-
 IMP
-
 Oryctolagus cuniculus
6.3.4.4 0.2
-
 IMP
-
 Schizosaccharomyces pombe
6.3.4.4 0.2 0.7 IMP muscle enzyme Rattus norvegicus
6.3.4.4 0.23
-
 Asp
-
 Escherichia coli
6.3.4.4 0.23
-
 Asp
-
 Sus scrofa
6.3.4.4 0.25 0.36 Asp muscle enzyme Rattus norvegicus
6.3.4.4 0.29 0.3 Asp
-
 Oryctolagus cuniculus
6.3.4.4 0.308
-
 Asp
-
 Escherichia coli
6.3.4.4 0.308
-
 Asp heart enzyme Rattus norvegicus
6.3.4.4 0.33
-
 Asp
-
 Oryctolagus cuniculus
6.3.4.4 0.33
-
 Asp liver basic type L isozyme Rattus norvegicus
6.3.4.4 0.36 1.47 Asp acidic liver type L isozym Rattus norvegicus
6.3.4.4 0.43
-
 Asp
-
 Triticum aestivum
6.3.4.4 0.43
-
 Asp
-
 Leishmania donovani
6.3.4.4 0.5
-
 Asp
-
 Azotobacter vinelandii
6.3.4.4 0.68
-
 Asp
-
 Bacillus subtilis
6.3.4.4 0.69
-
 IMP liver basic isozyme Rattus norvegicus
6.3.4.4 0.7
-
 IMP skeletal muscle Rattus norvegicus
6.3.4.4 0.95 1.16 Asp
-
 Homo sapiens
6.3.4.4 1.5
-
 Asp
-
 Schizosaccharomyces pombe

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.4.4 additional information
-
 Gallus gallus
6.3.4.4 additional information
-
 Bacillus subtilis
6.3.4.4 additional information
-
 Escherichia coli
6.3.4.4 additional information
-
 Homo sapiens
6.3.4.4 additional information
-
 Rattus norvegicus
6.3.4.4 additional information
-
 Sus scrofa
6.3.4.4 additional information
-
 Triticum aestivum
6.3.4.4 additional information
-
 Oryctolagus cuniculus
6.3.4.4 additional information
-
 Schizosaccharomyces pombe
6.3.4.4 additional information
-
 Leishmania donovani
6.3.4.4 additional information
-
 Azotobacter vinelandii
6.3.4.4 additional information
-
 Trypanosoma cruzi

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.4.4 55000 60000 liver and Novikoff ascites cells Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.4 Azotobacter vinelandii
-
-
-
6.3.4.4 Bacillus subtilis
-
-
-
6.3.4.4 Escherichia coli
-
-
-
6.3.4.4 Gallus gallus
-
-
-
6.3.4.4 Homo sapiens
-
-
-
6.3.4.4 Leishmania donovani
-
-
-
6.3.4.4 Oryctolagus cuniculus
-
-
-
6.3.4.4 Rattus norvegicus
-
 2 isozymic forms: acidic type L, and basic type M
-
6.3.4.4 Schizosaccharomyces pombe
-
-
-
6.3.4.4 Sus scrofa
-
-
-
6.3.4.4 Triticum aestivum
-
-
-
6.3.4.4 Trypanosoma cruzi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.4 brain
-
 Rattus norvegicus
-
6.3.4.4 heart
-
 Rattus norvegicus
-
6.3.4.4 heart
-
 Oryctolagus cuniculus
-
6.3.4.4 kidney
-
 Rattus norvegicus
-
6.3.4.4 liver
-
 Homo sapiens
-
6.3.4.4 liver
-
 Rattus norvegicus
-
6.3.4.4 liver
-
 Oryctolagus cuniculus
-
6.3.4.4 additional information tissue distribution of L-isozyme and M-isozyme Rattus norvegicus
-
6.3.4.4 muscle
-
 Rattus norvegicus
-
6.3.4.4 muscle
-
 Oryctolagus cuniculus
-
6.3.4.4 Novikoff ascites tumor cell
-
 Rattus norvegicus
-
6.3.4.4 placenta
-
 Homo sapiens
-
6.3.4.4 spleen
-
 Rattus norvegicus
-
6.3.4.4 Yoshida ascites sarcoma cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.4 GTP + 2'-dIMP + L-Asp
-
 Oryctolagus cuniculus GDP + phosphate + 2'-deoxysuccinoAMP
-
 ?
6.3.4.4 GTP + 2'-dIMP + L-Asp
-
 Leishmania donovani GDP + phosphate + 2'-deoxysuccinoAMP
-
 ?
6.3.4.4 GTP + 2'-dIMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + 2'-deoxysuccinoAMP
-
 ?
6.3.4.4 GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
-
 Leishmania donovani GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
 ?
6.3.4.4 GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide
-
 ?
6.3.4.4 GTP + 8-azaIMP + L-Asp
-
 Leishmania donovani GDP + phosphate + 8-azasuccinoAMP
-
 ?
6.3.4.4 GTP + 8-azaIMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + 8-azasuccinoAMP
-
 ?
6.3.4.4 GTP + beta-D-arabinosylIMP + L-Asp
-
 Oryctolagus cuniculus GDP + phosphate + arabinosylsuccinoAMP
-
 ?
6.3.4.4 GTP + beta-D-arabinosylIMP + L-Asp
-
 Leishmania donovani GDP + phosphate + arabinosylsuccinoAMP
-
 ?
6.3.4.4 GTP + beta-D-arabinosylIMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + arabinosylsuccinoAMP
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Gallus gallus GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Bacillus subtilis GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Escherichia coli GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Homo sapiens GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Rattus norvegicus GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Sus scrofa GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Triticum aestivum GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Oryctolagus cuniculus GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Schizosaccharomyces pombe GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Leishmania donovani GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Azotobacter vinelandii GDP + phosphate + adenylosuccinate
-
 ?
6.3.4.4 GTP + IMP + L-Asp
-
 Trypanosoma cruzi GDP + phosphate + adenylosuccinate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.4 7.7 8.7
-
 Leishmania donovani