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Literature summary extracted from

  • Tatibana, M.; Shigesada, K.
    Two carbamyl phosphate synthetases of mammals: specific roles in control of pyrimidine and urea biosynthesis (1972), Adv. Enzyme Regul., 10, 249-271.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.3.4.16 acetylglutamate
-
 Mus musculus
6.3.4.16 acetylglutamate allosteric activator Rattus norvegicus
6.3.4.16 acetylglutamate allosteric activator Mammalia

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.4.16 mitochondrion
-
 Rattus norvegicus 5739
-
6.3.4.16 mitochondrion
-
 Mammalia 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.4.16 2 ATP + NH3 + CO2 + H2O Rattus norvegicus
-
 ?
-
 ?
6.3.4.16 2 ATP + NH3 + CO2 + H2O Mammalia enzyme is involved in arginine and urea synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.16 Mammalia
-
-
-
6.3.4.16 Mus musculus
-
-
-
6.3.4.16 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.16 liver
-
 Rattus norvegicus
-
6.3.4.16 liver
-
 Mus musculus
-
6.3.4.16 liver
-
 Mammalia
-
6.3.4.16 small intestine
-
 Mammalia
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.4.16 1.5
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.16 2 ATP + NH3 + CO2 + H2O
-
 Rattus norvegicus ?
-
 ?
6.3.4.16 2 ATP + NH3 + CO2 + H2O enzyme is involved in arginine and urea synthesis Mammalia ?
-
 ?
6.3.4.16 ATP + NH4+ + CO2 + H2O
-
 Mammalia ADP + phosphate + carbamoylphosphate
-
 ?
6.3.4.16 ATP + NH4+ + CO2 + H2O
-
 Mus musculus ADP + phosphate + carbamoylphosphate
-
 ?
6.3.4.16 ATP + NH4+ + CO2 + H2O
-
 Rattus norvegicus ADP + phosphate + carbamoylphosphate
-
 ?