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Literature summary extracted from

  • Duhaiman, A.S.
    Kinetic properties of camel lens zeta-crystallin (1996), Int. J. Biochem. Cell Biol., 28, 1163-1168.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.5.5 2,3-Dimercaptopropanol
-
 Camelus dromedarius
1.6.5.5 5,5'-dithiobis(2-nitrobenzoate)
-
 Camelus dromedarius
1.6.5.5 ADP 10% inhibition at 0.2 mM Camelus dromedarius
1.6.5.5 Cu2+ 25% inhibition at 1 mM Camelus dromedarius
1.6.5.5 dicoumarol
-
 Camelus dromedarius
1.6.5.5 dithiothreitol strong competitive inhibition with respect to 9,10-phenanthrenequinone Camelus dromedarius
1.6.5.5 FAD 60% inhibition at 0.2 mM Camelus dromedarius
1.6.5.5 FMN 40% inhibition at 0.2 mM Camelus dromedarius
1.6.5.5 NAD+ 5% inhibition at 0.2 mM Camelus dromedarius
1.6.5.5 NADP+ mixed-type inhibition with respect to NADPH, competitive with respect to 9,10-phenanthrenequinone Camelus dromedarius
1.6.5.5 NEM
-
 Camelus dromedarius
1.6.5.5 warfarin
-
 Camelus dromedarius
1.6.5.5 Zn2+ 25% inhibition at 1 mM Camelus dromedarius

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.5.5 0.0024
-
 1,2-naphthoquinone
-
 Camelus dromedarius
1.6.5.5 0.0069
-
 NADPH
-
 Camelus dromedarius
1.6.5.5 0.013
-
 oxidized 2,6-dichlorophenolindophenol
-
 Camelus dromedarius
1.6.5.5 0.017
-
 9,10-phenanthrenequinone
-
 Camelus dromedarius
1.6.5.5 0.065
-
 1,4-benzoquinone
-
 Camelus dromedarius
1.6.5.5 0.26
-
 1,4-Naphthoquinone
-
 Camelus dromedarius

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.5 Camelus dromedarius
-
 camel
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.6.5.5 NADPH + H+ + 2 quinone = NADP+ + 2 semiquinone reaction with 9,10-phenanthrenequinone and NADPH proceeds through a ping-pong mechanism Camelus dromedarius
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.5 lens
-
 Camelus dromedarius
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.5 1,2-naphthoquinone + NADPH
-
 Camelus dromedarius 1,2-naphthoquinol + NADP+
-
 ?
1.6.5.5 1,4-benzoquinone + NADPH
-
 Camelus dromedarius 1,4-benzosemiquinone + NADP+
-
 ?
1.6.5.5 1,4-naphthoquinone + NADPH + H+
-
 Camelus dromedarius 1,4-naphthosemiquinone + NADP+
-
 ?
1.6.5.5 9,10-phenanthrenequinone + NADPH best substrate Camelus dromedarius 9,10-phenanthrenesemiquinone + NADP+
-
 ?
1.6.5.5 NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Camelus dromedarius NADP+ + reduced 2,6-dichlorophenolindophenol
-
 ?