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Literature summary extracted from

  • Lassy, R.A.L.; Miller, C.G.
    Peptidase E, a peptidase specific for N-terminal aspartic dipeptides, is a serine hydrolase (2000), J. Bacteriol., 182, 2536-2543.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.13.21
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21
-
 Xenopus laevis

Protein Variants

EC Number Protein Variants Comment Organism
3.4.13.21 K95A active mutant Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21 R171A inactive mutant Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21 R171E inactive mutant Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21 R174E inactive mutant Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21 S120C not inhibited by iodoacetate, N-ethylmaleimide, trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.13.21 iodoacetate inhibition of wild-type but not of S120C mutant Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21 N-ethylmaleimide inhibition of wild-type but not of S120C mutant Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21 trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64, inhibition of wild-type but not of S120C mutant Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
3.4.13.21 Salmonella enterica subsp. enterica serovar Typhimurium
-
 GenBank accession number P36936
-
3.4.13.21 Xenopus laevis
-
 GenBank accession number AAC59869
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.13.21
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.4.13.21
-
 Xenopus laevis

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.13.21 0.0014
-
 substrate L-Asp-4-nitroanilide Xenopus laevis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.13.21 L-Asp-4-nitroanilide + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-Asp + 4-nitroaniline
-
 ?
3.4.13.21 L-Asp-4-nitroanilide + H2O
-
 Xenopus laevis L-Asp + 4-nitroaniline
-
 ?
3.4.13.21 L-Asp-Gly-Gly + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
3.4.13.21 L-Asp-Gly-Gly + H2O
-
 Xenopus laevis ?
-
 ?
3.4.13.21 L-Asp-L-His + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-Asp + L-His
-
 ?
3.4.13.21 L-Asp-L-His + H2O
-
 Xenopus laevis L-Asp + L-His
-
 ?
3.4.13.21 L-Asp-L-Leu + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium L-Asp + L-Leu
-
 ?
3.4.13.21 L-Asp-L-Leu + H2O
-
 Xenopus laevis L-Asp + L-Leu
-
 ?