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Literature summary extracted from

  • Kloor, D.; Kurz, J.; Fuchs, S.; Faust, B.; Osswald, H.
    S-adenosylhomocysteine-hydrolase from bovine kidney: Enzymatic and binding properties (1996), Kidney Blood Press. Res., 19, 100-108.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 2'-deoxyadenosine
-
 Bos taurus
3.13.2.1 adenine
-
 Bos taurus
3.13.2.1 adenosine
-
 Bos taurus
3.13.2.1 adenosine-5'-monophosphate
-
 Bos taurus
3.13.2.1 ATP
-
 Bos taurus
3.13.2.1 cAMP
-
 Bos taurus
3.13.2.1 Inosine
-
 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.13.2.1 0.005
-
 S-adenosyl-L-homocysteine
-
 Bos taurus
3.13.2.1 0.0056
-
 adenosine
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.13.2.1 190000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O Bos taurus
-
 adenosine + L-homocysteine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.13.2.1 205fold to homogeneity Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 kidney
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.13.2.1 0.25
-
-
 Bos taurus

Storage Stability

EC Number Storage Stability Organism
3.13.2.1 -20°C, stability of the adenosine binding site is reduced from Kd 6.8 to 29 nM within 4 months Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Bos taurus adenosine + L-homocysteine
-
 r