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Literature summary extracted from

  • Impagnatiello, A.; Franceschini, N.; Oratore, A.; Bozzi, A.
    Inhibition studies of S-adenosylhomocysteine hydrolase purified from Acinetobacter calcoaceticus ULA-501 (1996), Biochimie, 78, 267-272.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 2'-deoxyadenosine
-
Acinetobacter calcoaceticus
3.13.2.1 2'-deoxyadenosine
-
Bos taurus
3.13.2.1 2-chloroadenosine
-
Acinetobacter calcoaceticus
3.13.2.1 2-chloroadenosine
-
Bos taurus
3.13.2.1 3-deaza-(+/-)-aristeromycin
-
Acinetobacter calcoaceticus
3.13.2.1 3-deaza-(+/-)-aristeromycin
-
Bos taurus
3.13.2.1 3-deazaadenosine
-
Acinetobacter calcoaceticus
3.13.2.1 3-deazaadenosine
-
Bos taurus
3.13.2.1 cis-diaminedichloride platinum
-
Acinetobacter calcoaceticus
3.13.2.1 cis-diaminedichloride platinum
-
Bos taurus
3.13.2.1 KCl with ATP-Mg acetate Acinetobacter calcoaceticus
3.13.2.1 KCl with ATP-Mg acetate Bos taurus
3.13.2.1 sinefungin
-
Acinetobacter calcoaceticus
3.13.2.1 trans-diaminedichloride platinum
-
Acinetobacter calcoaceticus
3.13.2.1 trans-diaminedichloride platinum
-
Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.13.2.1 0.0016
-
adenosine
-
Acinetobacter calcoaceticus
3.13.2.1 0.008
-
adenosine
-
Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O Bos taurus
-
adenosine + L-homocysteine
-
r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Acinetobacter calcoaceticus
-
adenosine + L-homocysteine
-
r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Acinetobacter calcoaceticus ULA-501
-
adenosine + L-homocysteine
-
r

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Acinetobacter calcoaceticus
-
ULA-501
-
3.13.2.1 Acinetobacter calcoaceticus ULA-501
-
ULA-501
-
3.13.2.1 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.13.2.1 to homogeneity Acinetobacter calcoaceticus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Bos taurus
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Acinetobacter calcoaceticus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 pancreas
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 DL-homocysteine + adenosine
-
Bos taurus S-adenosyl-DL-homocysteine
-
r
3.13.2.1 DL-homocysteine + adenosine
-
Acinetobacter calcoaceticus S-adenosyl-DL-homocysteine
-
r
3.13.2.1 DL-homocysteine + adenosine
-
Acinetobacter calcoaceticus ULA-501 S-adenosyl-DL-homocysteine
-
r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
Bos taurus adenosine + L-homocysteine
-
r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
Acinetobacter calcoaceticus adenosine + L-homocysteine
-
r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
Acinetobacter calcoaceticus ULA-501 adenosine + L-homocysteine
-
r

Subunits

EC Number Subunits Comment Organism
3.13.2.1 hexamer
-
Acinetobacter calcoaceticus

Cofactor

EC Number Cofactor Comment Organism Structure
3.13.2.1 NAD+
-
Bos taurus