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Literature summary extracted from

  • Jarvi, E.T.; McCarthy, J.R.; Mehdi, S.; Matthews, D.P.; Edwards, M.L.; Prakash, N.J.; Bowlin, T.L.; Sunkara, P.S.; Bey, P.
    4',5'-Unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase (1991), J. Med. Chem., 34, 647-656.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.13.2.1 adenosine prevents inhibition by (Z)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine Mus musculus

Application

EC Number Application Comment Organism
3.13.2.1 medicine antiviral drug design Mus musculus
3.13.2.1 medicine antiviral drug design Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 (E)-4',5'-didehydro-2',5'-dideoxy-5'-fluoroadenosine
-
 Rattus norvegicus
3.13.2.1 (E)-4',5'-didehydro-5'-deoxy-5'-chloro-5'-fluoroadenosine competitive Rattus norvegicus
3.13.2.1 (E)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Mus musculus
3.13.2.1 (E)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Rattus norvegicus
3.13.2.1 (E)-9-(5-deoxy-5-fluoro-beta-D-threo-pent-4-enofuranosyl)-9H-purin-6-amine competitive Rattus norvegicus
3.13.2.1 (Z)-4',5'-didehydro-2',5'-dideoxy-5'-fluoroadenosine competitive Rattus norvegicus
3.13.2.1 (Z)-4',5'-didehydro-5'-chloro-5'-deoxyadenosine competitive Rattus norvegicus
3.13.2.1 (Z)-4',5'-didehydro-5'-deoxy-5'-chloro-5'-fluoroadenosine competitive Rattus norvegicus
3.13.2.1 (Z)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Mus musculus
3.13.2.1 (Z)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Rattus norvegicus
3.13.2.1 (Z)-9-(5-deoxy-5-fluoro-beta-D-threo-pent-4-enofuranosyl)-9H-purin-6-amine competitive Rattus norvegicus
3.13.2.1 5'-deoxy-5',5'-difluoradenosine
-
 Mus musculus
3.13.2.1 5'-deoxy-5',5'-difluoradenosine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O Mus musculus
-
 adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O Rattus norvegicus
-
 adenosine + L-homocysteine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Mus musculus
-
-
-
3.13.2.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.13.2.1
-
 Rattus norvegicus
3.13.2.1 partial Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Mus musculus
a
3.13.2.1 S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 liver
-
 Mus musculus
-
3.13.2.1 liver
-
 Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
3.13.2.1 -70°C Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 DL-homocysteine + adenosine
-
 Mus musculus S-adenosyl-DL-homocysteine
-
 r
3.13.2.1 DL-homocysteine + adenosine
-
 Rattus norvegicus S-adenosyl-DL-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Mus musculus adenosine + L-homocysteine
-
 r
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Rattus norvegicus adenosine + L-homocysteine
-
 r