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Literature summary extracted from

  • Wnuk, S.F.; Yuan, C.S.; Borchardt, R.T.; Balzarini, J.; De Clercq, E.; Robins, M.J.
    Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxyaldehydes and oximes synthesized from adenosine and sugar-modified analogues (1997), J. Med. Chem., 40, 1608-1628.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.13.2.1 medicine antiviral drug design Homo sapiens
3.13.2.1 medicine chemotherapeutic drug design Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.13.2.1 9-(2-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
3.13.2.1 9-(2-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
3.13.2.1 9-(3-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
3.13.2.1 9-(3-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
3.13.2.1 9-(alpha-L-lyxo-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
3.13.2.1 9-(alpha-L-lyxo-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
3.13.2.1 9-(beta-D-arabino-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
3.13.2.1 9-(beta-D-arabino-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
3.13.2.1 9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
3.13.2.1 9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine (adenosine-5'-carboxaldehyde)
-
 Homo sapiens
3.13.2.1 9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine O-benzyloxime (E/Z) Homo sapiens
3.13.2.1 9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine O-ethyloxime (E/Z) Homo sapiens
3.13.2.1 9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine O-methyloxime (E/Z) Homo sapiens
3.13.2.1 9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O Homo sapiens
-
 adenosine + L-homocysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.13.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.13.2.1 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.13.2.1 S-adenosyl-L-homocysteine + H2O
-
 Homo sapiens adenosine + L-homocysteine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
3.13.2.1 NAD+
-
 Homo sapiens