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Literature summary extracted from
- S-Adenosyl-L-homocysteine hydrolase from mouse leukemic cells: Isolation and properties (1983), Collect. Czech. Chem. Commun., 48, 2701-2708.
No PubMed abstract available
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | medicine | antimalaric drug design | Mus musculus |
| 3.13.2.1 | medicine | antiviral drug design | Mus musculus |
| 3.13.2.1 | medicine | chemotherapeutic drug design | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | (2R)-3-(adenin-9-yl)-2-hydroxypropanoic acid | - |
Mus musculus |  |
| 3.13.2.1 | (2S)-3-(adenin-9-yl)-2-hydroxypropanoic acid | - |
Mus musculus | |
| 3.13.2.1 | 9-(2,3-Dihydroxypropyl)adenine | - |
Mus musculus | |
| 3.13.2.1 | D-eritadenine | - |
Mus musculus | |
| 3.13.2.1 | L-eritadenine | - |
Mus musculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.0038 | - |
adenosine | - |
Mus musculus | |
| 3.13.2.1 | 0.0044 | - |
S-adenosyl-L-homocysteine | - |
Mus musculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Mus musculus | - |
adenosine + L-homocysteine | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | to homogeneity | Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | L-1210 cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | additional information | - |
- |
Mus musculus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.13.2.1 | -70°C, with 20% glycerol, stable for several months | Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Mus musculus | adenosine + L-homocysteine | - |
r | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 47 | - |
hydrolysis of S-adenosyl-L-homocysteine | Mus musculus |
| 3.13.2.1 | 52 | - |
synthesis of S-adenosyl-L-homocysteine | Mus musculus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | additional information | - |
- |
Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 7 | 7.2 | synthesis of S-adenosyl-L-homocysteine | Mus musculus |
| 3.13.2.1 | 7.2 | 7.8 | hydrolysis of S-adenosyl-L-homocysteine | Mus musculus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | additional information | - |
- |
Mus musculus |
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