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Literature summary extracted from
- Purification and characterization of S-adenosylhomocysteine hydrolase from mouse mastocytoma P-815 cells. Evidence for cell cycle-specific fluctuation of the enzyme activity (1985), J. Biochem., 97, 189-197.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.13.2.1 | 2'-deoxyadenosine | - |
Mus musculus |  |
| 3.13.2.1 | 2-Aminoadenosine | - |
Mus musculus | |
| 3.13.2.1 | 2-chloroadenosine | - |
Mus musculus | |
| 3.13.2.1 | adenine | - |
Mus musculus | |
| 3.13.2.1 | adenosine-5'-monophosphate | poor | Mus musculus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.13.2.1 | 0.00029 | - |
adenosine | - |
Mus musculus | |
| 3.13.2.1 | 0.00077 | - |
S-adenosyl-L-homocysteine | - |
Mus musculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 45000 | - |
probably homotetramer, 4 * 45000, SDS-PAGE | Mus musculus |
| 3.13.2.1 | 190000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | Mus musculus | - |
adenosine + L-homocysteine | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.13.2.1 | 260fold to homogeneity | Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.13.2.1 | P-815 cell | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | additional information | - |
- |
Mus musculus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.13.2.1 | 4°C | Mus musculus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.13.2.1 | DL-homocysteine + adenosine | - |
Mus musculus | S-adenosyl-DL-homocysteine | - |
r | |
| 3.13.2.1 | S-adenosyl-L-homocysteine + H2O | - |
Mus musculus | adenosine + L-homocysteine | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.13.2.1 | tetramer | probably homotetramer, 4 * 45000, SDS-PAGE | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.13.2.1 | 7 | 7.2 | hydrolysis of S-adenosyl-L-homocysteine | Mus musculus |
| 3.13.2.1 | 7.8 | 8 | synthesis of S-adenosyl-L-homocysteine | Mus musculus |
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