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Literature summary extracted from

  • Nolan, L.L.; Kidder, G.W.
    Inhibition of growth and purine-metabolizing enzymes of trypanosomid flagellates by N6-methyladenine (1980), Antimicrob. Agents Chemother., 17, 567-571.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.7 6-Methylaminopurine growth inhibition by addition to culture media Crithidia fasciculata
3.2.2.7 6-Methylaminopurine growth inhibition by addition to culture media Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.7 adenosine + H2O Crithidia fasciculata component of the purine salvage pathway 6-aminopurine + D-ribofuranose
-
 ?
3.2.2.7 adenosine + H2O Trypanosoma cruzi component of the purine salvage pathway 6-aminopurine + D-ribofuranose
-
 ?
3.2.2.7 adenosine + H2O Crithidia fasciculata 6-aminopurine-9-beta-D-ribofuranoside 6-aminopurine + D-ribofuranose
-
 ?
3.2.2.7 adenosine + H2O Trypanosoma cruzi 6-aminopurine-9-beta-D-ribofuranoside 6-aminopurine + D-ribofuranose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.7 Crithidia fasciculata
-
-
-
3.2.2.7 no activity in Leishmania braziliensis
-
-
-
3.2.2.7 no activity in Leishmania donovani
-
-
-
3.2.2.7 no activity in Leishmania mexicana
-
-
-
3.2.2.7 no activity in Leishmania tarentolae
-
-
-
3.2.2.7 Trypanosoma cruzi
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.7 cell culture growth inhibition by 6-methylaminopurine Crithidia fasciculata
-
3.2.2.7 cell culture growth inhibition by 6-methylaminopurine Trypanosoma cruzi
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.7 adenosine + H2O component of the purine salvage pathway Crithidia fasciculata 6-aminopurine + D-ribofuranose
-
 ?
3.2.2.7 adenosine + H2O component of the purine salvage pathway Trypanosoma cruzi 6-aminopurine + D-ribofuranose
-
 ?
3.2.2.7 adenosine + H2O 6-aminopurine-9-beta-D-ribofuranoside Crithidia fasciculata 6-aminopurine + D-ribofuranose
-
 ?
3.2.2.7 adenosine + H2O 6-aminopurine-9-beta-D-ribofuranoside Trypanosoma cruzi 6-aminopurine + D-ribofuranose
-
 ?