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Literature summary extracted from
- Nicotinamide adenine dinucleotide glycohydrolases from Ehrlich ascites tumor cell nuclei: isolation, partial purification and properties (1972), Biochemistry, 11, 4108-4113.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 3.2.2.5 | chromatin NADase is sensitiv to Dnase | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.2.2.5 | additional information | nuclear membrane NADase is insensitiv to 1 M NaCl | Mus musculus | |
| 3.2.2.5 | NaCl | 0.5 M or more, 65% loss in activity, irreversible, DNA associated NADase | Mus musculus |  |
| 3.2.2.5 | nicotinamide | 0.33 mM, 50% inhibition | Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.2.2.5 | nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.2.5 | NAD+ + H2O | Mus musculus | - |
ADPribose + nicotinamide | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.2.2.5 | Mus musculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.2.2.5 | partial | Mus musculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.2.2.5 | Ehrlich ascites carcinoma cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.2.2.5 | NAD+ + H2O | - |
Mus musculus | ADPribose + nicotinamide | - |
? | |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.2.2.5 | 45 | - |
2 min, 100% inactivation, DNA associated NADase | Mus musculus |
| 3.2.2.5 | 45 | - |
5 min, stable, nuclear membrane NADase | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.2.2.5 | 6.3 | 7 | nuclear membrane | Mus musculus |
| 3.2.2.5 | 6.6 | 7.1 | DNA associated NADase | Mus musculus |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.2.2.5 | 0.33 | - |
nicotinamide | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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