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Literature summary extracted from

  • Legler, G.
    beta-Glucocerebrosidase: mechanistic studies with covalent and non-covalent inhibitors (1988), NATO ASI Ser. A, Life Sci., 150, 63-72.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.45 (1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
-
 Bos taurus
3.2.1.45 (1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
-
 Homo sapiens
3.2.1.45 (1R,2R,3S,4S,5R,6S)-7-oxabicyclo[4.1.0]heptane-2,3,4,5-tetrol
-
 Rattus norvegicus
3.2.1.45 1-deoxynojirimycin
-
 Bos taurus
3.2.1.45 1-deoxynojirimycin
-
 Homo sapiens
3.2.1.45 6-bromo-6-deoxy-conduritol
-
 Bos taurus
3.2.1.45 6-bromo-6-deoxy-conduritol
-
 Homo sapiens
3.2.1.45 6-bromo-6-deoxy-conduritol
-
 Mus musculus
3.2.1.45 6-bromo-conduritol-beta-epoxide
-
 Bos taurus
3.2.1.45 6-bromo-conduritol-beta-epoxide
-
 Homo sapiens
3.2.1.45 6-bromo-conduritol-beta-epoxide
-
 Mus musculus
3.2.1.45 glucal
-
 Homo sapiens
3.2.1.45 gluconolactone
-
 Bos taurus
3.2.1.45 gluconolactone
-
 Homo sapiens
3.2.1.45 glucose at 220 mM Homo sapiens
3.2.1.45 glucosylsphingosine
-
 Homo sapiens
3.2.1.45 glucosylsphingosine
-
 Rattus norvegicus
3.2.1.45 glycosylamine
-
 Homo sapiens
3.2.1.45 N-hexyl-D-glucosylsphingosine
-
 Homo sapiens
3.2.1.45 N-hexyl-D-glucosylsphingosine
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.45 0.03
-
 beta-D-glucocerebroside
-
 Homo sapiens
3.2.1.45 0.17
-
 4-nonylumbelliferyl-beta-D-glucopyranoside
-
 Homo sapiens
3.2.1.45 1.9
-
 4-methylumbelliferyl-beta-D-glucopyranoside
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.45 glucocerebroside + H2O Mus musculus
-
 glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O Homo sapiens
-
 glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O Rattus norvegicus
-
 glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O Sus scrofa
-
 glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O Bos taurus
-
 glucose + ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.45 Bos taurus
-
-
-
3.2.1.45 Homo sapiens
-
-
-
3.2.1.45 Mus musculus
-
-
-
3.2.1.45 Rattus norvegicus
-
-
-
3.2.1.45 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Mus musculus methylumbelliferone + glucose
-
 ?
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Homo sapiens methylumbelliferone + glucose
-
 ?
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Rattus norvegicus methylumbelliferone + glucose
-
 ?
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Sus scrofa methylumbelliferone + glucose
-
 ?
3.2.1.45 4-methylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Bos taurus methylumbelliferone + glucose
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Mus musculus glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Homo sapiens glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Rattus norvegicus glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Sus scrofa glucose + ceramide
-
 ?
3.2.1.45 glucocerebroside + H2O
-
 Bos taurus glucose + ceramide
-
 ?
3.2.1.45 nonylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Mus musculus nonylumbelliferone + glucose
-
 ?
3.2.1.45 nonylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Homo sapiens nonylumbelliferone + glucose
-
 ?
3.2.1.45 nonylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Rattus norvegicus nonylumbelliferone + glucose
-
 ?
3.2.1.45 nonylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Sus scrofa nonylumbelliferone + glucose
-
 ?
3.2.1.45 nonylumbelliferyl-beta-D-glucopyranoside + H2O
-
 Bos taurus nonylumbelliferone + glucose
-
 ?