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Literature summary extracted from

  • Brooks, D.A.; Gibson, G.J.; Hopwood, J.J.
    Immunochemical characterization of feline and human N-acetylgalactosamine 4-sulfatase (1994), Biochem. Med. Metab. Biol., 53, 58-66.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.6.12 medicine enzyme replacement in MPS IV feline fibroblast Homo sapiens
3.1.6.12 medicine enzyme replacement in MPS IV feline fibroblast Felis catus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.6.12 expression in CHO cells Felis catus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.6.12 13000
-
 1 * 57000, composed of 2 peptides 1 * 43000, 1 * 13000 Homo sapiens
3.1.6.12 43000
-
 gel filtration, SDS-PAGE Homo sapiens
3.1.6.12 43000
-
 gel filtration, SDS-PAGE Felis catus
3.1.6.12 43000
-
 under reducing conditions Homo sapiens
3.1.6.12 43000
-
 under reducing conditions Felis catus
3.1.6.12 57000
-
 1 * 57000, composed of 2 peptides 1 * 43000, 1 * 13000 Homo sapiens
3.1.6.12 57000 61000 diffuse band, unreduced PAGE Homo sapiens
3.1.6.12 57000 61000 diffuse band, unreduced PAGE Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Homo sapiens acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Felis catus acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.12 Felis catus
-
 siamese cat, feline model of human Maroteaux-Lamy Syndrom
-
3.1.6.12 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.6.12
-
 Felis catus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.12 brain
-
 Homo sapiens
-
3.1.6.12 brain
-
 Felis catus
-
3.1.6.12 fibroblast in culture Felis catus
-
3.1.6.12 kidney
-
 Homo sapiens
-
3.1.6.12 kidney
-
 Felis catus
-
3.1.6.12 leukocyte
-
 Felis catus
-
3.1.6.12 liver
-
 Homo sapiens
-
3.1.6.12 liver
-
 Felis catus
-
3.1.6.12 spleen
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.12 4-methylumbelliferyl sulfate + H2O
-
 Homo sapiens 4-methylumbelliferone + sulfate
-
 ?
3.1.6.12 4-methylumbelliferyl sulfate + H2O
-
 Felis catus 4-methylumbelliferone + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Homo sapiens N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Felis catus N-acetyl-D-galactosamine units + sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.6.12 monomer
-
 Felis catus
3.1.6.12 monomer 1 * 57000, composed of 2 peptides 1 * 43000, 1 * 13000 Homo sapiens